DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8306 and FAR1

DIOPT Version :9

Sequence 1:	NP_611140.3	Gene:	CG8306 / 36857	FlyBaseID:	FBgn0034142	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_011518702.1	Gene:	FAR1 / 84188	HGNCID:	26222	Length:	518	Species:	Homo sapiens

Alignment Length:	522	Identity:	178/522 - (34%)
Similarity:	293/522 - (56%)	Gaps:	27/522 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASSPITDFYAGRNVFITGATGFVGVTIVEKLLRDVPNVGTLYLLMRAKKGKSVQERLEELKKNS 65
            |.|.|  ::|.|:||.:||||||:|..::|||||..|.|.::|:|:|.|.|::.|||:||:....
Human     1 MVSIP--EYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGK 63

  Fly    66 VFDKFKELQLQSRLSKIVPIEGDVGLEHLGISPKDRQTLIDNVNVVFHSAATLDFFQSLKETTNI 130
            :||:.::.....| .||:.|..::....|.:|.:|::.:||:.|::||.|||:.|.::|::...:
Human    64 LFDRLRDENPDFR-EKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQL 127

  Fly   131 NLRGTRRVVELCQQIKNLDALVHVSSAYVNAYLTKVEEKLYPAPEDPEKIIQLSETLNDDALKEL 195
            |:..||:::.|.||:|||:..:|||:||.......::|.:||.|.||:|:|...|.::|..:.::
Human   128 NVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDI 192

  Fly   196 EPKLLKDHPNTYTFTKHLAEHEVANVASKFPCGIVRPSMITAAWKEPIPGWTISKNGPQGFFMGA 260
            .|||:.|.||||.:||.|||:.|....:|....|||||::.|:||||.|||..:.|||.|.|:.|
Human   193 TPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAA 257

  Fly   261 SKGVLRRLPLDPSIIMDYIPIDVVVNGIITTGYY--VNSLQAKNGGRPADLQIFHLTSSTYKPFR 323
            .||:||.:....:.:.|.:|:|||||..:...:|  ||...     ||.::.:::.|:.:..||.
Human   258 GKGILRTIRASNNALADLVPVDVVVNMSLAAAWYSGVNRYM-----RPRNIMVYNCTTGSTNPFH 317

  Fly   324 FELMTDKINSYLHDYPLNSAVWYPNLRLVKSLWVFRLSAILFHFIPAIILDLVTKIGGGRP---- 384
            :..:...:.|.....||..|...||:.|..:..::.....:.|..||.:.|:..::.|..|
Human   318 WGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMK 382

  Fly   385 ILVRLHKNVWNSLNTLEKFIFTEWHFDSKRLLALSKTLNIVDKKKFFIDIGELAWDEYFSNTILG 449
            .:.||||    ::..||.|....|.::::.:..|...||..|||.|.||:.:|.|.||..|..||
Human   383 TITRLHK----AMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLG 443

  Fly   450 VRQYLSKEPIKNLEKARRKDKILLGLHVALQLSFWYGVFKLIVCLT-GISTAKAALVLPVLYYLF 513
            .::|:..|.:..|..||:        |:....:..||...::|.|. .|..|::.:...:.|::.
Human   444 TKKYVLNEEMSGLPAARK--------HLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVV 500

  Fly   514 GL 515
            .|
Human   501 SL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8306	NP_611140.3	PLN02996	6..456	CDD:215538	162/455 (36%)
		FAR-N_SDR_e	13..339	CDD:187547	123/327 (38%)
		FAR_C	364..454	CDD:176924	30/93 (32%)
FAR1	XP_011518702.1	PLN02996	2..449	CDD:215538	164/458 (36%)
		FAR-N_SDR_e	11..333	CDD:187547	123/327 (38%)
		Sterile	360..450	CDD:281068	31/93 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56516
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860