DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8306 and FAR2

DIOPT Version :9

Sequence 1:	NP_611140.3	Gene:	CG8306 / 36857	FlyBaseID:	FBgn0034142	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_011519049.1	Gene:	FAR2 / 55711	HGNCID:	25531	Length:	535	Species:	Homo sapiens

Alignment Length:	509	Identity:	161/509 - (31%)
Similarity:	275/509 - (54%)	Gaps:	14/509 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SPITDFYAGRNVFITGATGFVGVTIVEKLLRDVPNVGTLYLLMRAKKGKSVQERLEELKKNSVFD 68
            |.|..||.|:::.|||||||:|..::|||.|..|::..:|:|:|.|.|:::|:|:.::..:.:|:
Human    22 STIAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFE 86

  Fly    69 KFKELQLQSRLSKIVPIEGDVGLEHLGISPKDRQTLIDNVNVVFHSAATLDFFQSLKETTNINLR 133
            |.||: ..:...||..|..|:......||.:|.|.|:...|::||.|||:.|..:|:....:|:.
Human    87 KVKEV-CPNVHEKIRAIYADLNQNDFAISKEDMQELLSCTNIIFHCAATVRFDDTLRHAVQLNVT 150

  Fly   134 GTRRVVELCQQIKNLDALVHVSSAYVNAYLTKVEEKLYPAPEDPEKIIQLSETLNDDALKELEPK 198
            .||:::.:..|:..|:|.:|:|:||.|..|..::|.:||.|.:|:|||...|.|:|..:.|:.||
Human   151 ATRQLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPK 215

  Fly   199 LLKDHPNTYTFTKHLAEHEVANVASKFPCGIVRPSMITAAWKEPIPGWTISKNGPQGFFMGASKG 263
            |::|.||.||:||.|.|..|...:......|:|||::.|.|:||.|||..:.|||.|..:...||
Human   216 LIRDWPNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKG 280

  Fly   264 VLRRLPLDPSIIMDYIPIDVVVNGIITTGYYVNSLQAKNGGRPADLQIFHLTSSTYKPFRFELMT 328
            .||.:...|..:.|.||:|.|||.::..|:|...      .||....::|:||....|..:..|.
Human   281 FLRAIKATPMAVADVIPVDTVVNLMLAVGWYTAV------HRPKSTLVYHITSGNMNPCNWHKMG 339

  Fly   329 DKINSYLHDYPLNSAVWYPNLRLVKSLWVFRLSAILFHFIPAIILDLVTKIGGGRPILVRLHKNV 393
            .::.:.....|.......||.....:.:..:....:.|..||||.|...::.|.:|.:.:|...:
Human   340 VQVLATFEKIPFERPFRRPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGRKPRMTKLMNRL 404

  Fly   394 WNSLNTLEKFIFTEWHFDSKRLLALSKTLNIVDKKKFFIDIGELAWDEYFSNTILGVRQYLSKEP 458
            ..:::.||.||...|.:.:.....|...|:..|::.|..|:.:|.|.||..|.:|||::||.||.
Human   405 LRTVSMLEYFINRSWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKED 469

  Fly   459 IKNLEKARRKDKILLGLHVALQLSFWYGVFKLIVCLTGISTAKAALVLPVLYYL 512
            :..:.||:::.|.|..:|.....:.:...::|::       |::.:...|.:::
Human   470 MAGIPKAKQRLKRLRNIHYLFNTALFLIAWRLLI-------ARSQMARNVWFFI 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8306	NP_611140.3	PLN02996	6..456	CDD:215538	150/449 (33%)
		FAR-N_SDR_e	13..339	CDD:187547	114/325 (35%)
		FAR_C	364..454	CDD:176924	27/89 (30%)
FAR2	XP_011519049.1	PLN02996	22..467	CDD:215538	151/451 (33%)
		FAR-N_SDR_e	31..335	CDD:187547	113/310 (36%)
		Sterile	377..467	CDD:281068	29/89 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56516
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760