DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8306 and CG30427

DIOPT Version :9

Sequence 1:	NP_611140.3	Gene:	CG8306 / 36857	FlyBaseID:	FBgn0034142	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001246512.1	Gene:	CG30427 / 37986	FlyBaseID:	FBgn0043792	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	168/509 - (33%)
Similarity:	284/509 - (55%)	Gaps:	26/509 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SPITDFYAGRNVFITGATGFVGVTIVEKLLRDVPNVGTLYLLMRAKKGKSVQERLEELKKNSVFD 68
            ||:.::|..:.:|||||:||:|..::||||....::..:.::.|.|:||:.:.||||:.|..:|.
  Fly     6 SPVQEYYKDKTIFITGASGFMGKVLLEKLLYSCHSLKEVIIICRPKRGKAPETRLEEMFKLPIFQ 70

  Fly    69 KFKELQLQSRLSKIVPIEGDVGLEHLGISPKDRQTLIDNVNVVFHSAATLDFFQSLKETTNINLR 133
            :.|: :....|.::...:|||..:.||:|.:..:.:.:|.|:|||.||||....:|::..::||.
  Fly    71 RIKD-ERPEMLKRVTIYQGDVTFDQLGLSGESLKHVTENTNIVFHMAATLKLEGNLRDAIDMNLL 134

  Fly   134 GTRRVVELCQQIKNLDALVHVSSAYVNAYLTKVEEKLYPAPEDPEKIIQLSETLNDDALKELEPK 198
            ||||.:.:.:::|.|:|.:|:|:|:.|.....:.||:|..|..||.:::|:|.::...|..:.|.
  Fly   135 GTRRALNVAKEMKQLEAFIHLSTAFCNCDQDVMYEKVYEFPHKPEDLMRLAEWMDVKTLDAITPD 199

  Fly   199 LLKDHPNTYTFTKHLAEHEVANVASKFPCGIVRPSMITAAWKEPIPGWTISKNGPQGFFMGASKG 263
            |||.||||||::|.|||..|.:.....|..|.|||::|.|..||:|||..:.|||.|..:||.||
  Fly   200 LLKPHPNTYTYSKRLAELLVRDHYESMPVIIARPSIVTPAVAEPLPGWVDNMNGPTGVLIGAGKG 264

  Fly   264 VLRRLPLDPSIIMDYIPIDVVVNGIITTGYYVNSLQAKNGGRPADLQIFHLTSSTYKPFRFELMT 328
            |:|.:..:..:..:.||:|:.:||:|...|: |||..|   ||..:.:::||....|...::.:.
  Fly   265 VIRSMICNGELKSEVIPVDIAINGLILLPYH-NSLAEK---RPLQIPVYNLTVDDAKKRTWKWIM 325

  Fly   329 DKINSYLHDYPLNSAVWYPNLRLVKSLWVFRLSAILFHFIPAIILDLVTKIGGGRPILVRLHKNV 393
            |........||....:|||:..:..|.:...:..|||.::||.::|.:..|.|.|..::|:...:
  Fly   326 DVGRDLGIKYPFEVGLWYPDGNMTSSKFYHTICTILFMWLPAYLIDFLLLIFGQRRFMIRVQTKI 390

  Fly   394 WNSLNTLEKFIFTEWHFDSKRLLALSKTLNIVDKKKFFIDIGELAWDEYFSNTILGVRQYLSKEP 458
            ...|..|:.|....|.|.|.....:.|.|...|::.|.|:..::...||...:|||.|||:.|||
  Fly   391 AVGLEVLQFFTTRSWDFKSTHFEQIYKELGSTDRRIFKINTDDVDDYEYMKVSILGGRQYVMKEP 455

  Fly   459 IKNLEKARRKDKILLGLHVALQLSFWYGVFKLIVCLTGISTAKAALVLPVLYYL 512
            :.:|.|:|            :||.|.|.:.:  :|       |..::..:||::
  Fly   456 LTSLPKSR------------IQLRFMYVLDR--IC-------KTMIISGLLYWV 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8306	NP_611140.3	PLN02996	6..456	CDD:215538	152/449 (34%)
		FAR-N_SDR_e	13..339	CDD:187547	116/325 (36%)
		FAR_C	364..454	CDD:176924	27/89 (30%)
CG30427	NP_001246512.1	FAR-N_SDR_e	15..321	CDD:187547	115/310 (37%)
CG30427	NP_001246512.1	Sterile	364..453	CDD:281068	26/88 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466804
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.900