DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8306 and CG8303

DIOPT Version :9

Sequence 1:	NP_611140.3	Gene:	CG8306 / 36857	FlyBaseID:	FBgn0034142	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001286495.1	Gene:	CG8303 / 36858	FlyBaseID:	FBgn0034143	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	159/525 - (30%)
Similarity:	277/525 - (52%)	Gaps:	35/525 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSPITDFYAGRNVFITGATGFVGVTIVEKLLRDVPNVGTLYLLMRAKKGKSVQERLEELKKNSVF 67
            |..|.:|:|.:|:|:||.|||:|..::|.||...|::||:|:|:|.|:.....||:..|.:..:|
  Fly    36 SLTIPEFFAHKNIFVTGGTGFLGTVLIEALLDTHPDIGTIYVLVRGKRKFDPNERIRRLLQKPIF 100

  Fly    68 DKFKELQLQSRLSKIVPIEGDVGLEHLGISPKDRQTLIDNVNVVFHSAATLDFFQSLKETTNINL 132
            :|:.|    ..|||:||:.|::...:.|..|:..|.|||.|||::|||||:.|...|:.....||
  Fly   101 EKYSE----KTLSKVVPVVGELSEPNFGFGPELLQELIDRVNVIYHSAATIKFSSPLRTAIRTNL 161

  Fly   133 RGTRRVVELCQQIKNLDALVHVSSAYVNA-YLTKVEEKLYPAPEDPEKIIQLSETLNDDALKELE 196
            .||.|.:||.:|:|.|.|.::.|:|:.|: ....:.|::|.:..||.::::::|  :|.|.::..
  Fly   162 TGTMRTIELAKQLKQLAAYIYCSTAFCNSNNRGLIAEEVYKSQFDPYEMMKMAE--DDSAWEDFT 224

  Fly   197 PK----LLKDHPNTYTFTKHLAEHEVANVASKFPCGIVRPSMITAAWKEPIPGWTISKN-GPQGF 256
            .:    .::||||||||||:|:|:.:....|..|..|||||::....:.|:.||..:.| |..||
  Fly   225 DQKCKGYIRDHPNTYTFTKNLSENLLMAEMSGLPAAIVRPSIVYGTLEHPMKGWVGNANSGHLGF 289

  Fly   257 FMGASKGVLRRLPLDPSIIMDYIPIDVVVNGIITTGYYVNSLQAKNGGRPADLQIFHLTSSTYKP 321
            ..|..||:.|.:..:.:.::|.||.|.|:|..:..|:||.:.:.:   :|   :|.|.||....|
  Fly   290 LAGFVKGIFRTMCGNANAVIDIIPCDYVINSSLVMGWYVGTRKLE---QP---EIIHCTSGEVNP 348

  Fly   322 FRFELMTDKINSYLHDYPLNSAVWYPNLRLVKSLWVFRLSAILFHFIPAIILDLVTKIGG-GRPI 385
            .........||..:..:|.||.||.|..:| ::.|.:.|...|||.:||::..:..|:.| |.|
  Fly   349 LNLAEFCTIINDSVERHPPNSFVWKPVTKL-RNGWRYNLFFYLFHLLPAMVFIIPEKLFGIGMP- 411

  Fly   386 LVRLHKNVWNSLNTLEK-------FIFTEWHFDSKRLLALSKTLNIVDKKKFFIDIGELAWDEYF 443
                ....:..:...:|       |:..::.:..|..|.:|..:...|::::..|..:..|.|:.
  Fly   412 ----QHTAYEYMRVFQKGTKAFDYFLDKDFRYSLKNALRISALIPESDRRRYNFDASQCDWSEFI 472

  Fly   444 SNTILGVRQYLSKEPIKNLEKARRKDKILLGLHVALQLSFWYGVFKLIVCLTGISTAKAALVLPV 508
            ...::|:|::..||.....:..|...|:...|:.|..:..:..::..:....|:   :..|.|.|
  Fly   473 DRCLIGIRRFYFKESAVTTDWHRNYWKVFNVLYYAGYVVIFAVLYFALTLTLGL---QIGLTLAV 534

  Fly   509 LYYLF 513
            |.:.|
  Fly   535 LIWGF 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8306	NP_611140.3	PLN02996	6..456	CDD:215538	146/463 (32%)
		FAR-N_SDR_e	13..339	CDD:187547	114/331 (34%)
		FAR_C	364..454	CDD:176924	20/97 (21%)
CG8303	NP_001286495.1	FAR-N_SDR_e	46..366	CDD:187547	114/331 (34%)
CG8303	NP_001286495.1	Sterile	392..485	CDD:281068	18/97 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466813
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000