Protein Alignment Dolk and DOLK

DIOPT Version :10

• Sequence 1: NP_611139.1
• Gene: Dolk / 36856
• FlyBaseID: FBgn0034141
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_055723.1
• Gene: DOLK / 22845
• HGNCID: 23406
• Length: 538
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 170/518 - (32%)
• Similarity: 244/518 - (47%)
• Gaps: 104/518 - (20%)

  Fly    38 QRTDVFSLKAMAPRPNAG--PGGWLCLLLPLALTVRLLRHATPACKDQARMQCLLTVAAGGMAL- 99
            |.:.||..:..|   |:|  |...:..||.|.:..|......|..:     :..:.|||.|||:
Human    66 QGSAVFQFRMSA---NSGLLPASMVMPLLGLVMKERCQTAGNPFFE-----RFGIVVAATGMAVA 122

  Fly   100 ---ETLCFFIYAFVKTGILVKCLVSLLPGVAT-----SLSFYLLVDTSLTFAIIVGFVMTSAYQQ 156
               ..|...|...|.|...|  ::.|..||..     |||...:::......|.|...|
Human   123 LFSSVLALGITRPVPTNTCV--ILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNM------ 179

  Fly   157 IYIYTLRGFQRSFTYGEASVFVQGLVLFALSAIHRLGGFFCGGSWPTEEFDTLNMIMVNAL---- 217
            |.:|.|   .|.||.|||.     |||..:|.:                   ||.::..:|
Human   180 ILLYLL---PRCFTPGEAL-----LVLGGISFV-------------------LNQLIKRSLTLVE 217

  Fly   218 -------FCLLVFCVALVL----FPTL---------RKPCRFYLWTVMLLLAVTCMP----VTRP 258
                   |.|||..|.:||    |.||         .....|:|.|.:|.|.|. :|    :.|.
Human   218 SQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVV-LPWLHRLIRR 281

  Fly   259 LPLLALVQFLLRDQERLAILVFYMLLVVLTCLTVAWQ----IGSSAK---ANTRVRKIFHLLIVM 316
            .|||.|:|||.:...|:.:|.::.||..|.||.|.:|    ..|.:|   |.|..||.|||::|.
Human   282 NPLLWLLQFLFQTDTRIYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVA 346

  Fly   317 VYIPGLIFECALLYLATGVALAAFVVLELLRLLKIPPFADRLAVAFSTFKDEKDAGELALTPFCL 381
            .||||:||:..|||:|..|.||.|:.||.:|..:|.|....|....|.|.||:|:|.|.||...|
Human   347 TYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYL 411

  Fly   382 LIGCSMPIWMTPCPCS------GDNTLALLSGILAVGVGDTAASVVGSKLGRNKWGRSSRSLEGT 440
            |:|.|:|||:.|.||:      |...|...:|:||||||||.||:.||.:|..:|..:.::.|||
Human   412 LLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGT 476

  Fly   441 IAFVVSILMAVWLLEI--SGLVAMSQAKWFATIFAALNS-ALVEAFTDQVDNLVLPLIFYTIV 500
            :..:.:.:::|.|:.|  ||:.......|   |..:::: :|:||:|.|:|||:|||  |.::
Human   477 MTSIFAQIISVALILIFDSGVDLNYSYAW---ILGSISTVSLLEAYTTQIDNLLLPL--YLLI 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dolk	NP_611139.1	SEC59	306..495	CDD:439940	82/197 (42%)
DOLK	NP_055723.1	SEC59	333..524	CDD:439940	78/193 (40%)
		CTP-binding. /evidence=ECO:0000269|PubMed:16923818	459..474		3/14 (21%)