Protein Alignment Dolk and Dolk

DIOPT Version :10

• Sequence 1: NP_611139.1
• Gene: Dolk / 36856
• FlyBaseID: FBgn0034141
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_808316.1
• Gene: Dolk / 227697
• MGIID: 2677836
• Length: 534
• Species: Mus musculus
• Alignment Length: 517
• Identity: 166/517 - (32%)
• Similarity: 241/517 - (46%)
• Gaps: 104/517 - (20%)

  Fly    38 QRTDVFSLKAMAPRPNAG--PGGWLCLLLPLALTVRLLRHATPACKDQARMQCLLTVAAGGMAL- 99
            |...||..:..|   |:|  |...:..||.|.:..|......|..:     :..:.|||.|||:
Mouse    64 QGNAVFQFRMSA---NSGLLPASMVMPLLGLVMKERCQTAGNPYFE-----RFGIVVAATGMAVA 120

  Fly   100 ---ETLCFFIYAFVKTGILVKCLVSLLPG------VATSLSFYLLVDTSLTFAIIVGFVMTSAYQ 155
               ..|...|...|.|.   .|.:|.|.|      :..|||...:::......|.|...|
Mouse   121 LFSSVLALGITRPVPTN---TCAISGLAGGVIIYIMRHSLSVGEVIEVLEVLLIFVYLNM----- 177

  Fly   156 QIYIYTLRGFQRSFTYGEASVFVQGLVLFALSAIHRLGGFFCGGSWPTEEFDTLNMIMVNAL--- 217
             |.:|.|   .|.||.|||.     |||..:|.:                   ||.::..:|
Mouse   178 -ILLYLL---PRCFTPGEAL-----LVLGGISFV-------------------LNQLIKRSLTES 214

  Fly   218 ------FCLLVFCVALVL----FPTL---------RKPCRFYLWTVMLLLAVTCMP----VTRPL 259
                  |.|||..|.:||    |.||         .....|:|.|.:|.|.|. :|    :.|..
Mouse   215 QGDPVDFFLLVVVVGMVLMGVFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVV-LPWLHWLIRRN 278

  Fly   260 PLLALVQFLLRDQERLAILVFYMLLVVLTCLTVAWQIGSSA-------KANTRVRKIFHLLIVMV 317
            |||.|:|||...:.|:.:|.::.||..:.||.|.:|....:       :|.|..||.||.::|..
Mouse   279 PLLWLLQFLFYTETRIYLLAYWSLLASVACLVVLYQNAKRSSSESKKHRAPTITRKYFHFIVVAT 343

  Fly   318 YIPGLIFECALLYLATGVALAAFVVLELLRLLKIPPFADRLAVAFSTFKDEKDAGELALTPFCLL 382
            ||||:||:..|||:|..|.||.|:.||.:|..:|.|....|....|.|.||:|:|.|.||...||
Mouse   344 YIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLL 408

  Fly   383 IGCSMPIWMTPCPCS------GDNTLALLSGILAVGVGDTAASVVGSKLGRNKWGRSSRSLEGTI 441
            :|.|:|||:.|.||:      |...|...:|:||||||||.||:.||.:|..:|..:.::.|||:
Mouse   409 LGMSLPIWLIPRPCTQKDSLEGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTM 473

  Fly   442 AFVVSILMAVWLLEI--SGLVAMSQAKWFATIFAALNS-ALVEAFTDQVDNLVLPLIFYTIV 500
            ..:.:.:::|.|:.|  ||:.......|   |..:::: :|:||:|.|:|||:|||  |.::
Mouse   474 TSIFAQIISVALILIFDSGVDLNYSYAW---ILGSISTVSLLEAYTTQIDNLLLPL--YLLI 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dolk	NP_611139.1	SEC59	306..495	CDD:439940	81/197 (41%)
Dolk	NP_808316.1	SEC59	329..520	CDD:439940	81/199 (41%)
		CTP-binding. /evidence=ECO:0000250|UniProtKB:Q9UPQ8	455..470		4/14 (29%)