Protein Alignment Cdk4 and CDK11B

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_011540792.1
• Gene: CDK11B / 984
• HGNCID: 1729
• Length: 804
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 129/300 - (43%)
• Similarity: 183/300 - (61%)
• Gaps: 17/300 - (5%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREI-SLLKQLNASNHANIV 89
            :|.||.|.||.||.||||:|..|..|||||::::...:.|.|:::|||| ::||    :.|.|||
Human   447 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK----AQHPNIV 507

  Fly    90 KLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRII 154
            .:.|:......|   .|.:|..:||.||..|::.: |....|..::.|..:||.||..||.:.|:
Human   508 TVREIVVGSNMD---KIYIVMNYVEHDLKSLMETM-KQPFLPGEVKTLMIQLLRGVKHLHDNWIL 568

  Fly   155 HRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLL-AQPYNSTVDIWSA 217
            |||||..|||:|..|.||:.|||||:.|||.:| .|.|||||||||||:|| |:.|::.||:||.
Human   569 HRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSV 633

  Fly   218 ACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP---QTISVALEHFPQRHP--KRPKDF 277
            .||..|:..::.||||.||.:|::::|:..|.|:|:.||   :..:|....|.: ||  ...|.|
Human   634 GCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSE-HPYNNLRKRF 697

  Fly   278 CPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQEPL 317
            ...|.....||:||.|:|....|.||...|:|:||::.||
Human   698 GALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPL 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	125/293 (43%)
CDK11B	XP_011540792.1	STKc_CDC2L1	441..732	CDD:173741	125/293 (43%)