Protein Alignment Cdk4 and CDK1

DIOPT Version :9

• Sequence 1: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001307847.1
• Gene: CDK1 / 983
• HGNCID: 1722
• Length: 297
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 128/296 - (43%)
• Similarity: 176/296 - (59%)
• Gaps: 19/296 - (6%)

  Fly    25 NYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIV 89
            :|.::..||||.||.||:.|...||.:||:||:|:...|.|||.:.:|||||||:|   .|.|||
Human     3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL---RHPNIV 64

  Fly    90 KLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSG-MSPPTIQRLSRELLTGVDFLHSHRI 153
            .|.:|   |.:|.:|  .|:||.:..||...:|.:|... |....::....::|.|:.|.||.|:
Human    65 SLQDV---LMQDSRL--YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124

  Fly   154 IHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKL-TSVVVTLWYRAPEVLLAQP-YNSTVDIWS 216
            :||||||||||:..:|.:|:||||||:.:|..::: |..|||||||:|||||... |::.|||||
Human   125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWS 189

  Fly   217 AACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPK-RPKDFCPH 280
            ...|..|:..::.||.|.||.:||.|||...|.|..:.||:..|  |:.:....|| :|.....|
Human   190 IGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES--LQDYKNTFPKWKPGSLASH 252

  Fly   281 LCKYAD----DLLNKMLSYDLHLRPSALACLEHDYF 312
            : |..|    |||:|||.||...|.|....|.|.||
Human   253 V-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	126/293 (43%)
		S_TKc	26..312	CDD:214567	126/293 (43%)
CDK1	NP_001307847.1	STKc_CDK1_euk	3..287	CDD:270845	126/294 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810