DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk4 and Cdk4

DIOPT Version :9

Sequence 1:	NP_001286493.1	Gene:	Cdk4 / 36854	FlyBaseID:	FBgn0016131	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	XP_038935924.1	Gene:	Cdk4 / 94201	RGDID:	621120	Length:	313	Species:	Rattus norvegicus

Alignment Length:	227	Identity:	105/227 - (46%)
Similarity:	147/227 - (64%)	Gaps:	0/227 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 VKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRI 153
            |:|.:||.....|..:.:.|||||::|||...:|:.|..|:...||:.|.|:.|:|:||||::.|
  Rat    82 VRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCI 146

  Fly   154 IHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSAA 218
            :||||||:|:||:|.|.:|:||||||:.|..:|.||.||||||||||||||...|.:.||:||..
  Rat   147 VHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVG 211

  Fly   219 CIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLCK 283
            ||..|||.|:.||.|.||.:||.:||:|.|.|.|..||:.:|:....|..|.|:..:...|.:.:
  Rat   212 CIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFSPRGPRPVQSVVPEMEE 276

  Fly   284 YADDLLNKMLSYDLHLRPSALACLEHDYFQQE 315
            ....||.:||:::...|.||...|:|.|..:|
  Rat   277 SGAQLLLEMLTFNPLKRISAFRALQHSYLHKE 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	103/222 (46%)
Cdk4	NP_001286493.1	S_TKc	26..312	CDD:214567	103/222 (46%)
Cdk4	XP_038935924.1	PKc_like	<82..305	CDD:419665	103/222 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I1657
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2838
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D419040at33208
OrthoFinder	1	1.000	-	-		FOG0004605
OrthoInspector	1	1.000	-	-		otm45619
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2222
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.930