Protein Alignment Cdk4 and CDK13

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_016868239.1
• Gene: CDK13 / 8621
• HGNCID: 1733
• Length: 1542
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 115/361 - (31%)
• Similarity: 184/361 - (50%)
• Gaps: 66/361 - (18%)

  Fly     6 QLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMST 70
            :.|.:.:...|:..|    .:..:.|||||.||.||:|||..||.:|||||||:...:.|.|::.
Human   689 ETKEKDIDWGKRCVD----KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITA 749

  Fly    71 LREISLLKQLNASNHANIVKLYEV-------CQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSG 128
            :|||.:|:||   .|.:|:.:.|:       ..|.:..|  ...||||:::.||..|::    ||
Human   750 IREIKILRQL---THQSIINMKEIVTDKEDALDFKKDKG--AFYLVFEYMDHDLMGLLE----SG 805

  Fly   129 M---SPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSE----- 185
            :   :...|:...|:|:.|:|:.|....:|||:|..|:|::::|.:|:||||||:.|.||
Human   806 LVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESAWL 870

  Fly   186 ---------------MKL------------TSVVVTLWYRAPEVLLAQP-YNSTVDIWSAACIIF 222
                           |::            |:.|:|||||.||:||.:. |...:|:||..||:.
Human   871 MLIWEKVIFIWRILLMQMSAGSFGDSSRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILG 935

  Fly   223 EMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRP------KDFCPHL 281
            |:|.::.:|....|..||:.|..:.|.|....||..|.  |.:|....||:.      ::|. .:
Human   936 ELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK--LPYFNTMKPKKQYRRKLREEFV-FI 997

  Fly   282 CKYADDLLNKMLSYDLHLRPSALACLEHDYFQQ-EP 316
            ...|.||.:.||:.|...|.:|...|:.::.:. ||
Human   998 PAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEP 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	110/334 (33%)
CDK13	XP_016868239.1	STKc_CDK12	697..1028	CDD:270847	112/346 (32%)