Protein Alignment Cdk4 and CDC28

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_009718.3
• Gene: CDC28 / 852457
• SGDID: S000000364
• Length: 298
• Species: Saccharomyces cerevisiae
• Alignment Length: 302
• Identity: 128/302 - (42%)
• Similarity: 181/302 - (59%)
• Gaps: 15/302 - (4%)

  Fly    21 GDPFNYQELNIIGEGAYGTVYRARDVITG---NIVALKKVRISLNENGVPMSTLREISLLKQLNA 82
            |:..||:.|..:|||.||.||:|.|:..|   .:|||||:|:...:.|||.:.:|||||||:|..
Yeast     3 GELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKD 67

  Fly    83 SNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPK-SGMSPPTIQRLSRELLTGVD 146
            .   |||:||::   :..|...| .||||.::.||...::.:|| ..:....:::...:|..|:.
Yeast    68 D---NIVRLYDI---VHSDAHKL-YLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIA 125

  Fly   147 FLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLL-AQPYN 209
            :.|||||:||||||||||::..|:||:.|||||:.:|..:: .|..:|||||||||||| .:.|:
Yeast   126 YCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYS 190

  Fly   210 STVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVA--LEHFPQRHPK 272
            :.||.||..||..||.||:.:|.|.||.:|:.:||.:.|.|.|..||..:.:.  ...|||...|
Yeast   191 TGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRK 255

  Fly   273 RPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQ 314
            ......|.|.....|||:|:|:||...|.||.....|.|||:
Yeast   256 DLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQE 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	123/293 (42%)
CDC28	NP_009718.3	STKc_CDK1_CdkB_like	8..295	CDD:270829	123/293 (42%)