Protein Alignment Cdk4 and HOG1

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_013214.1
• Gene: HOG1 / 850803
• SGDID: S000004103
• Length: 435
• Species: Saccharomyces cerevisiae
• Alignment Length: 302
• Identity: 109/302 - (36%)
• Similarity: 151/302 - (50%)
• Gaps: 39/302 - (12%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVK 90
            |.:||.:|.||:|.|..|.|.:|...||:||:....:...:...|.||:.|||.|   .|.|::.
Yeast    23 YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHL---RHENLIC 84

  Fly    91 LYEVCQFLE--RDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRI 153
            |.::  ||.  .|    |..|.|....||..|:...|   :....:|....::|.|:.::||..:
Yeast    85 LQDI--FLSPLED----IYFVTELQGTDLHRLLQTRP---LEKQFVQYFLYQILRGLKYVHSAGV 140

  Fly   154 IHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLA-QPYNSTVDIWSA 217
            |||||||.|:|::....|||.|||||:....:|  |..|.|.:|||||::|. |.|:..||||||
Yeast   141 IHRDLKPSNILINENCDLKICDFGLARIQDPQM--TGYVSTRYYRAPEIMLTWQKYDVEVDIWSA 203

  Fly   218 ACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTI--SVALEH-------FPQRHP-- 271
            .||..||...:.||||....:|...|.:|.|.|     |:.:  ::..|:       .|.|.|
Yeast   204 GCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSP-----PKDVINTICSENTLKFVTSLPHRDPIP 263

  Fly   272 --KRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDY 311
              :|.|...|.    |.|||.|||.:|...|.:|...|.|.|
Yeast   264 FSERFKTVEPD----AVDLLEKMLVFDPKKRITAADALAHPY 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	109/302 (36%)
HOG1	NP_013214.1	STKc_Sty1_Hog1	12..339	CDD:270843	109/302 (36%)