Protein Alignment Cdk4 and CAK1

DIOPT Version :9

• Sequence 1: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_116624.1
• Gene: CAK1 / 850515
• SGDID: S000001865
• Length: 368
• Species: Saccharomyces cerevisiae
• Alignment Length: 253
• Identity: 69/253 - (27%)
• Similarity: 115/253 - (45%)
• Gaps: 69/253 - (27%)

  Fly    67 PMSTLREISLLKQL-NASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLI------DRL 124
            |.:...|:|:|.:| |...|  |:.|.|  .....:..||:|..||  |.:|.:.:      ||.
Yeast    41 PHNAKFEVSILNKLGNKCKH--ILPLLE--SKATDNNDLLLLFPFE--EMNLYEFMQMHYKRDRR 99

  Fly   125 PKSG-----------MSPPTIQRLS-------------RELLTGVDFLHSHRIIHRDLKPQNLLV 165
            .|:.           ::.|.:|:.:             |:::.|:.|||.::|||||:||||:::
Yeast   100 KKNPYYDLLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIAFLHENKIIHRDIKPQNIML 164

  Fly   166 SS-----QGHLKIADFGL-------AKTYGSEM--KLTSVVVTLWYRAPEVLL-AQPYNSTVDIW 215
            ::     ...|.|.|||:       ::|....|  |:|.:...: |:|||||. .:.|:..||:|
Yeast   165 TNNTSTVSPKLYIIDFGISYDMANNSQTSAEPMDSKVTDISTGI-YKAPEVLFGVKCYDGGVDVW 228

  Fly   216 SAACIIFEMFNRRA---------LFPGTSEKNQ-------LDRIFELTGRPTEQQWPQ 257
            |...||.:.|.|..         :..|:.:.|.       :..|||..|.|:.|:|.:
Yeast   229 SLLIIISQWFQRETSRMGHVPAMIDDGSDDMNSDGSDFRLICSIFEKLGIPSIQKWEE 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	69/253 (27%)
		S_TKc	26..312	CDD:214567	69/253 (27%)
CAK1	NP_116624.1	PKc_like	13..>234	CDD:419665	56/199 (28%)
		PKc_like	<135..363	CDD:419665	47/153 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900