Protein Alignment Cdk4 and CDK11A

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001300825.1
• Gene: CDK11A / 728642
• HGNCID: 1730
• Length: 783
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 127/299 - (42%)
• Similarity: 180/299 - (60%)
• Gaps: 15/299 - (5%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREI-SLLKQLNASNHANIV 89
            :|.||.|.||.||.||||:|..|..|||||::::...:.|.|:::|||| ::||    :.|.|||
Human   426 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK----AQHPNIV 486

  Fly    90 KLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRII 154
            .:.|:......|   .|.:|..:||.||..|::.: |....|..::.|..:||.||..||.:.|:
Human   487 TVREIVVGSNMD---KIYIVMNYVEHDLKSLMETM-KQPFLPGEVKTLMIQLLRGVKHLHDNWIL 547

  Fly   155 HRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLL-AQPYNSTVDIWSA 217
            |||||..|||:|..|.||:.|||||:.|||.:| .|.||||.||||||:|| |:.|::.||:||.
Human   548 HRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSV 612

  Fly   218 ACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP--QTISVALEHFPQRHP--KRPKDFC 278
            .||..|:..::.||||.||.:|::::|:..|.|:|:.||  ..:.|..:.....||  ...|.|.
Human   613 GCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFG 677

  Fly   279 PHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQEPL 317
            ..|.....||:||.|:|....|.||...|:|:||::.||
Human   678 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPL 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	123/292 (42%)
CDK11A	NP_001300825.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..396
		STKc_CDC2L1	420..711	CDD:173741	123/292 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..783