Protein Alignment Cdk4 and cdk5

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_571794.1
• Gene: cdk5 / 65234
• ZFINID: ZDB-GENE-010131-2
• Length: 292
• Species: Danio rerio
• Alignment Length: 295
• Identity: 131/295 - (44%)
• Similarity: 181/295 - (61%)
• Gaps: 20/295 - (6%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVK 90
            |::|..||||.||||::|::..|..|||||:||:..::.|||.|.||||.|||:|   .|.|||:
Zfish     4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL---KHKNIVR 65

  Fly    91 LYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIH 155
            |::|   |..|.:|  .||||:.:|||....|.. ...:.|..::....:||.|:.|.||..::|
Zfish    66 LHDV---LHSDKKL--TLVFEYCDQDLKKYFDSC-NGDLDPEIVKSFMYQLLKGLAFCHSRNVLH 124

  Fly   156 RDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSV-VVTLWYRAPEVLL-AQPYNSTVDIWSAA 218
            |||||||||::..|.||:||||||:.:|..::..|. |||||||.|:||. |:.|::::|:|||.
Zfish   125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAG 189

  Fly   219 CIIFEMFNR-RALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPK-----DF 277
            ||..|:.|. |.||||....:||.|||.|.|.|||:|| ||::...::.|  :|..|.     :.
Zfish   190 CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW-QTMNKLPDYKP--YPMYPATTSLVNV 251

  Fly   278 CPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF 312
            .|.|.....|||..:|..:...|.||...|:|.||
Zfish   252 VPKLSSTGRDLLQNLLKCNPVQRISAEEALQHPYF 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	129/293 (44%)
cdk5	NP_571794.1	STKc_CDK5	3..286	CDD:143344	129/293 (44%)