Protein Alignment Cdk4 and CDK15

DIOPT Version :9

• Sequence 1: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001353315.1
• Gene: CDK15 / 65061
• HGNCID: 14434
• Length: 435
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 131/330 - (39%)
• Similarity: 176/330 - (53%)
• Gaps: 46/330 - (13%)

  Fly     9 RQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLN-ENGVPMSTLR 72
            ||.....|....|...:|..|..:|||:|.|||:....|.|.:||||.  ||:| |.|||.:.:|
Human    86 RQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKV--ISMNAEEGVPFTAIR 148

  Fly    73 EISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRL 137
            |.||||.|   .|||||.|:::....|     .:..|||::..||:..:.:.| .|:.|..::..
Human   149 EASLLKGL---KHANIVLLHDIIHTKE-----TLTFVFEYMHTDLAQYMSQHP-GGLHPHNVRLF 204

  Fly   138 SRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAK-------TYGSEMKLTSVVVTL 195
            ..:||.|:.::|...::||||||||||:|..|.||:||||||:       ||.||      ||||
Human   205 MFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSE------VVTL 263

  Fly   196 WYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSE-KNQLDRIFELTGRPTEQQWPQT 258
            |||.|:.|| |..|:|.:|||.|.||..|||..:.||||.|. ..||::|:|:.|.|||..||
Human   264 WYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWP-- 326

  Fly   259 ISVALEHFPQRHPK-----RPKDFCPHL-------CKYADDLLNKMLSYDLHLRPSALACLEHDY 311
               .:...|..:|:     .|:..  |:       ...|:||.::||......|.||...|.|||
Human   327 ---GVSKLPNYNPEWFPLPTPRSL--HVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDY 386

  Fly   312 FQQEP 316
            |...|
Human   387 FSALP 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	124/307 (40%)
		S_TKc	26..312	CDD:214567	124/307 (40%)
CDK15	NP_001353315.1	STKc_PFTAIRE2	102..387	CDD:270852	124/308 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810