DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk4 and CDK14

DIOPT Version :9

Sequence 1:	NP_001286493.1	Gene:	Cdk4 / 36854	FlyBaseID:	FBgn0016131	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_001274064.1	Gene:	CDK14 / 5218	HGNCID:	8883	Length:	469	Species:	Homo sapiens

Alignment Length:	335	Identity:	130/335 - (38%)
Similarity:	183/335 - (54%)	Gaps:	48/335 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VRQLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPM 68
            ||:........:.|||..|  :|::|..:|||:|.|||:.:..:.|.:||||.:|:. .|.|.|.
Human   115 VRRHSSPSSPTSPKFGKAD--SYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPF 176

  Fly    69 STLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPT 133
            :.:||.||||.|   .|||||.|:::....|     .:.||||:|..||...:|:.| .|:.|..
Human   177 TAIREASLLKGL---KHANIVLLHDIIHTKE-----TLTLVFEYVHTDLCQYMDKHP-GGLHPDN 232

  Fly   134 IQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAK-------TYGSEMKLTSV 191
            ::....:||.|:.::|...|:||||||||||:|..|.||:||||||:       ||.:|
Human   233 VKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNE------ 291

  Fly   192 VVTLWYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSE-KNQLDRIFELTGRPTEQQ 254
            |||||||.|:||| :..|::.:|:|...||..||....|.|||..: ::||:|||.:.|.|.|..
Human   292 VVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDT 356

  Fly   255 WPQTISVALEHFPQRHPKRPKDFCPHLCK-------------YADDLLNKMLSYDLHLRPSALAC 306
            ||...|  |.||      :|:.|..:..|             :|:||.:|:|......|.||.|.
Human   357 WPGVHS--LPHF------KPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAA 413

  Fly   307 LEHDYFQQEP 316
            |.|:||...|
Human   414 LSHEYFSDLP 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	121/307 (39%)
Cdk4	NP_001286493.1	S_TKc	26..312	CDD:214567	121/307 (39%)
CDK14	NP_001274064.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..133		5/17 (29%)
		STKc_PFTAIRE1	129..431	CDD:143374	127/321 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..469
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810