DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdk4 and CDK12

DIOPT Version :10

Sequence 1:NP_477196.1 Gene:Cdk4 / 36854 FlyBaseID:FBgn0016131 Length:317 Species:Drosophila melanogaster
Sequence 2:NP_057591.2 Gene:CDK12 / 51755 HGNCID:24224 Length:1490 Species:Homo sapiens


Alignment Length:317 Identity:114/317 - (35%)
Similarity:173/317 - (54%) Gaps:37/317 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 DPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHA 86
            |.|:.  :.|||||.||.||:|:|..||.:|||||||:...:.|.|::.:|||.:|:||   .|.
Human   725 DKFDI--IGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQL---IHR 784

  Fly    87 NIVKLYEV-------CQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGM---SPPTIQRLSREL 141
            ::|.:.|:       ..|.:..|  ...||||:::.||..|::    ||:   |...|:...::|
Human   785 SVVNMKEIVTDKQDALDFKKDKG--AFYLVFEYMDHDLMGLLE----SGLVHFSEDHIKSFMKQL 843

  Fly   142 LTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSE--MKLTSVVVTLWYRAPEVLL 204
            :.|:::.|....:|||:|..|:|:::.|.:|:||||||:.|.||  ...|:.|:|||||.||:||
Human   844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLL 908

  Fly   205 AQP-YNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQ 268
            .:. |...:|:||..||:.|:|.::.:|....|..||:.|..|.|.|....||..|.  |.:|..
Human   909 GEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK--LPYFNT 971

  Fly   269 RHPKRPK--------DFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQEPL 317
            ..||:..        .|.|   ..|.|||:.||:.|...|.:|...|:.|:.:...|
Human   972 MKPKKQYRRRLREEFSFIP---SAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVEL 1025

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdk4NP_477196.1 STKc_CDK4_6_like 26..312 CDD:270831 111/306 (36%)
CDK12NP_057591.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..703
STKc_CDK12 719..1020 CDD:270847 113/310 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1098
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1189
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1348
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1460
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1466..1490
Blue background indicates that the domain is not in the aligned region.

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