DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk4 and CDK17

DIOPT Version :9

Sequence 1:	NP_001286493.1	Gene:	Cdk4 / 36854	FlyBaseID:	FBgn0016131	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_001163935.1	Gene:	CDK17 / 5128	HGNCID:	8750	Length:	523	Species:	Homo sapiens

Alignment Length:	318	Identity:	123/318 - (38%)
Similarity:	187/318 - (58%)	Gaps:	29/318 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLR 72
            :|.:.:...:.|.|....|.:|..:|||.|.|||:.|..:|.|:||||::|:. :|.|.|.:.:|
Human   174 RRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLE-HEEGAPCTAIR 237

  Fly    73 EISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRL 137
            |:||||.|   .|||||.|:::   :..|..|  .||||::::||...:|..... ||...::..
Human   238 EVSLLKDL---KHANIVTLHDI---VHTDKSL--TLVFEYLDKDLKQYMDDCGNI-MSMHNVKLF 293

  Fly   138 SRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLA-------KTYGSEMKLTSVVVTL 195
            ..::|.|:.:.|..:::||||||||||::.:|.||:||||||       |||.:|      ||||
Human   294 LYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNE------VVTL 352

  Fly   196 WYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTI 259
            |||.|:||| :..|::.:|:|...||.|||.:.|.||||::.:::|..||.|.|.|:::.|| .|
Human   353 WYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWP-GI 416

  Fly   260 SVALE----HFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            |...|    :||:..|:...:..|.|.....:|:.|.|.|:...|.||...::|.||:
Human   417 SSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	118/297 (40%)
Cdk4	NP_001286493.1	S_TKc	26..312	CDD:214567	118/297 (40%)
CDK17	NP_001163935.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..123
		STKc_PCTAIRE2	185..493	CDD:143377	122/307 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810