Protein Alignment Cdk4 and CDK16

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_011542222.1
• Gene: CDK16 / 5127
• HGNCID: 8749
• Length: 571
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 119/319 - (37%)
• Similarity: 186/319 - (58%)
• Gaps: 30/319 - (9%)

  Fly     5 RQLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMS 69
            |:|:|..:|:   .|.|....|.:|:.:|||.|.|||:.:..:|.|:||||::|:. :|.|.|.:
Human   221 RRLRRVSLSE---IGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCT 281

  Fly    70 TLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTI 134
            .:||:||||.|   .|||||.|:::.. .|:.    :.||||::::||...:|..... ::...:
Human   282 AIREVSLLKDL---KHANIVTLHDIIH-TEKS----LTLVFEYLDKDLKQYLDDCGNI-INMHNV 337

  Fly   135 QRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLA-------KTYGSEMKLTSVV 192
            :....:||.|:.:.|..:::||||||||||::.:|.||:||||||       |||.:|      |
Human   338 KLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE------V 396

  Fly   193 VTLWYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP 256
            ||||||.|::|| :..|::.:|:|...||.:||...|.||||::.:.||..||.:.|.|||:.||
Human   397 VTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP 461

  Fly   257 QTIS---VALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF 312
            ..:|   ....::|:...:......|.|.....|||.|:|.::...|.||...::|.:|
Human   462 GILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	112/296 (38%)
CDK16	XP_011542222.1	STKc_PCTAIRE1	236..532	CDD:270854	113/301 (38%)