Protein Alignment Cdk4 and cdk18

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001006837.1
• Gene: cdk18 / 448581
• XenbaseID: XB-GENE-489094
• Length: 462
• Species: Xenopus tropicalis
• Alignment Length: 320
• Identity: 126/320 - (39%)
• Similarity: 183/320 - (57%)
• Gaps: 30/320 - (9%)

  Fly     5 RQLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMS 69
            |.|:|..:|.   .|.|....|.:|:.:|||.|.||::.|..:|||:||||::|:. :|.|.|.:
 Frog   114 RLLRRASLSD---IGFGKLETYIKLDKLGEGTYATVFKGRSKLTGNLVALKEIRLE-HEEGAPCT 174

  Fly    70 TLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTI 134
            .:||:||||.|   .|:|||.|:::..     .:..:.||||:::.||...:|..... |....:
 Frog   175 AIREVSLLKNL---KHSNIVTLHDIIH-----TEYCLTLVFEYLDSDLKQYLDNCGNL-MCMHNV 230

  Fly   135 QRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLA-------KTYGSEMKLTSVV 192
            :....:||.|:.:.|..:|:||||||||||::.:|.||:||||||       |||.:|      |
 Frog   231 KIFMFQLLRGLSYCHRRKILHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNE------V 289

  Fly   193 VTLWYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP 256
            ||||||.|:||| :..|::.:|:|...||::||...|.:|||::.|.:|..||.|.|.|||:.||
 Frog   290 VTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGRPMFPGSTVKEELHLIFRLLGTPTEETWP 354

  Fly   257 QTIS---VALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            ...|   .....|||...:..|:..|.|.....|||:.:|.|:...|.||...|.|.||:
 Frog   355 GICSNKEFKGYGFPQYRTQPLKNHTPRLDSDGIDLLSSLLLYEDKKRISADMGLRHAYFK 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	118/296 (40%)
cdk18	NP_001006837.1	STKc_PCTAIRE3	126..413	CDD:270853	119/302 (39%)