Protein Alignment Cdk4 and MAK

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001229886.1
• Gene: MAK / 4117
• HGNCID: 6816
• Length: 648
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 110/299 - (36%)
• Similarity: 171/299 - (57%)
• Gaps: 28/299 - (9%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVR---ISLNENGVPMSTLREISLLKQLNASNHAN 87
            |..:..:|:|.||:|...:...:|.:||:|:::   .|.:|    ...|||:..||:|   ||||
Human     4 YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDE----CMNLREVKSLKKL---NHAN 61

  Fly    88 IVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLI-DR---LPKSGMSPPTIQRLSRELLTGVDFL 148
            ::||.||.:  |.|.   :..:||:::::|..|: ||   .|:|     .|:.:..::|.|:.|:
Human    62 VIKLKEVIR--ENDH---LYFIFEYMKENLYQLMKDRNKLFPES-----VIRNIMYQILQGLAFI 116

  Fly   149 HSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLL-AQPYNSTV 212
            |.|...|||:||:|||......:||||||||:...|:...|..|.|.||||||||| :..|:|.:
Human   117 HKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPI 181

  Fly   213 DIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALE---HFPQRHPKRP 274
            |:|:...|:.|::..|.|||||||.:::.:|.::.|.|.:..||:...:|..   .|||..|...
Human   182 DVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINL 246

  Fly   275 KDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            |...|:....|..|:.:||::|...||:|...|:|.|||
Human   247 KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	107/296 (36%)
MAK	NP_001229886.1	STKc_MAK_like	4..284	CDD:270824	107/296 (36%)