Protein Alignment Cdk4 and Cdk12

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 324
• Identity: 114/324 - (35%)
• Similarity: 184/324 - (56%)
• Gaps: 26/324 - (8%)

  Fly     8 KRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLR 72
            :|...:..:.:|:.....::.:..||||.||.||:|||..|.::|||||||:...:.|.|::.:|
  Fly   786 RRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVR 850

  Fly    73 EISLLKQLNASNHANIVKLYEV-------CQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGM- 129
            ||.:|:||   ||.|||.|:|:       .:|.:..|.  ..||||:::.||..|::    |||
  Fly   851 EIKILRQL---NHRNIVNLHEIVTDKQDAVEFRKDKGS--FYLVFEYMDHDLMGLLE----SGMV 906

  Fly   130 --SPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGS---EMKLT 189
              :......:.::||.|:::.|....:|||:|..|:|::::|.:|:||||||:.|.:   |...|
  Fly   907 DFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYT 971

  Fly   190 SVVVTLWYRAPEVLLAQP-YNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQ 253
            :.|:|||||.||:||.:. |..::|:||..||:.|:|.:|.||...:|..||:.|.::.|.|...
  Fly   972 NKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPA 1036

  Fly   254 QWPQTISVALEHF---PQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQ 314
            .||..|.:.|.|.   .:.|.:|.::....:...|.|||:|||..|...|.:|...|...:.::
  Fly  1037 VWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRK 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	112/302 (37%)
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	113/310 (36%)