Protein Alignment Cdk4 and Cdk8

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Alignment Length: 356
• Identity: 118/356 - (33%)
• Similarity: 179/356 - (50%)
• Gaps: 71/356 - (19%)

  Fly     6 QLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRA--RDVITGNIVALKKVRISLNENGVPM 68
            |::|.|:.        |.|||:... :|.|.||.||:|  ::...|...|||::    :..|:.|
  Fly    10 QIERTKVE--------DLFNYEGCK-VGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSM 61

  Fly    69 STLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLI--DRLPKSGMSP 131
            |..|||:||::|   .|.|::.|..|  ||..:.:.:.||: ::.|.||..:|  .|..|:....
  Fly    62 SACREIALLREL---KHQNVITLIRV--FLSHNDRKVFLLI-DYAEHDLWHIIKFHRAAKATKKQ 120

  Fly   132 PTIQR-----LSRELLTGVDFLHSHRIIHRDLKPQNLLV----SSQGHLKIADFGLAKTYGSEMK 187
            ..:.|     |..::|.|:.:|||:.::||||||.|:||    :.:|.:||||.|.|:.:.:.:|
  Fly   121 VVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLK 185

  Fly   188 ----LTSVVVTLWYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSE---------KN 238
                |..||||.||||||:|| |:.|...:|||:..||..|:.....:|....|         .:
  Fly   186 PLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHD 250

  Fly   239 QLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDF-------CPHLCKY-----------A 285
            ||||||.:.|.|.::.|..     ::..|:.| ...|||       | .|.||           |
  Fly   251 QLDRIFNVMGFPQDKDWED-----IKKMPEHH-TLTKDFKRSTYSTC-SLAKYMERHKIKPDSKA 308

  Fly   286 DDLLNKMLSYDLHLRPSALACLEHDYFQQEP 316
            ..||.|:|..|.:.|.::...::..|||:||
  Fly   309 FHLLQKLLLMDPNKRITSEQAMQDQYFQEEP 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	107/330 (32%)
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	109/333 (33%)