Protein Alignment Cdk4 and Cdk2

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_562342.4
• Gene: Cdk2 / 3291042
• VectorBaseID: AGAMI1_009397
• Length: 309
• Species: Anopheles gambiae
• Alignment Length: 296
• Identity: 121/296 - (40%)
• Similarity: 172/296 - (58%)
• Gaps: 14/296 - (4%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVK 90
            |..::.||||.||.||:|:|:.|.|.||||::|:.....|:|.:.:|||||||.|   .|.:||:
Mosquito    19 YDRVDKIGEGTYGVVYKAKDIRTQNYVALKRIRLDNETEGIPSTAMREISLLKDL---KHHSIVE 80

  Fly    91 LYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIH 155
            |::|...     ...|.:|||:::.||..::|| .||..:|..::....::|..:.:.|.:||:|
Mosquito    81 LFDVVII-----DASIYMVFEYLDMDLKKMLDR-HKSSFTPMLVKSYMHQMLDAIAYCHLNRILH 139

  Fly   156 RDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKL-TSVVVTLWYRAPEVLLAQP-YNSTVDIWSAA 218
            |||||||||:..:||:|:||||||:.....::: |..||||||||||:||... |...||.||..
Mosquito   140 RDLKPQNLLIDREGHIKLADFGLARAVNFPIRVYTHEVVTLWYRAPEILLGTKFYCVGVDTWSLG 204

  Fly   219 CIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP--QTISVALEHFPQRHPKRPKDFCPHL 281
            ||..||..:|.||||.||.:||.:||...|.|.|.:||  ..:|...|.||...|:...:...|.
Mosquito   205 CIFAEMILKRPLFPGDSEIDQLFKIFRQMGTPDETKWPGVSHLSDYKESFPYWEPQPLPNEMQHD 269

  Fly   282 CKYADDLLNKMLSYDLHLRPSALACLEHDYFQQEPL 317
            .. |..|..:::.||...|.|..:.:.|.||....|
Mosquito   270 LD-AHTLFCELMHYDPTKRLSPKSAMSHSYFDNVSL 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	118/289 (41%)
Cdk2	XP_562342.4	Protein Kinases, catalytic domain	19..299	CDD:473864	118/289 (41%)