Protein Alignment Cdk4 and mapk12a

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_571482.1
• Gene: mapk12a / 30681
• ZFINID: ZDB-GENE-990415-257
• Length: 363
• Species: Danio rerio
• Alignment Length: 303
• Identity: 109/303 - (35%)
• Similarity: 159/303 - (52%)
• Gaps: 18/303 - (5%)

  Fly    23 PFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHAN 87
            |..|::|..:|.||||||..|.|..||..||:||:......:.......||:.|||.:...|...
Zfish    22 PDRYKDLKQVGTGAYGTVCYALDRRTGAKVAIKKLHRPFQSDLFAKRAYRELRLLKHMKHDNVIG 86

  Fly    88 IVKLYEVCQFLERDGQLLILLVFEHVEQDLSDL--IDRLPKSGMSPPTIQRLSRELLTGVDFLHS 150
            :|.::.....|:|.....:::.|  :..||..|  ::||     |...:|.|..::|.|:.::|:
Zfish    87 LVDVFTADLSLDRFHNFYLVMPF--MGTDLGKLMKMERL-----SEERVQYLVYQMLKGLKYIHA 144

  Fly   151 HRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLA-QPYNSTVDI 214
            ..||||||||.||.::.:..|||.|||||:...|||  |..|||.|||||||:|: ..|..||||
Zfish   145 AGIIHRDLKPGNLAINEECELKILDFGLARQTDSEM--TGYVVTRWYRAPEVILSWMHYTQTVDI 207

  Fly   215 WSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPK-RPKD-- 276
            ||..||:.||...:.||.|....:||..|.::||.|:::...:..|....::..:.|: |.||
Zfish   208 WSVGCIMAEMLLGKPLFKGHDHLDQLMEIMKVTGTPSKEFTAKLQSEDARNYVTKLPRFRKKDLR 272

  Fly   277 -FCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQ--EP 316
             ..|::...|..:|..||..|...|.:|...|...:|.:  ||
Zfish   273 ILLPNVNPQAIKVLEGMLLLDPESRITAAEALAFPFFSEFREP 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	105/292 (36%)
mapk12a	NP_571482.1	Protein Kinases, catalytic domain	9..351	CDD:473864	109/303 (36%)
		TXY	181..183		1/1 (100%)