DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk4 and Cdk18

DIOPT Version :9

Sequence 1:	NP_001286493.1	Gene:	Cdk4 / 36854	FlyBaseID:	FBgn0016131	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_001093976.1	Gene:	Cdk18 / 289019	RGDID:	1309523	Length:	451	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	127/320 - (39%)
Similarity:	185/320 - (57%)	Gaps:	30/320 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RQLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMS 69
            |..:|..:|.   .|.|....|.:|:.:|||.|.||::.|..:|.|:||||::|:. :|.|.|.:
  Rat   103 RMSRRASLSD---IGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCT 163

  Fly    70 TLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTI 134
            .:||:||||.|   .|||||.|:::   :..|..|  .||||:::.||...:|..... |:...:
  Rat   164 AIREVSLLKDL---KHANIVTLHDL---IHTDRSL--TLVFEYLDSDLKQYLDHCGNL-MNMHNV 219

  Fly   135 QRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLA-------KTYGSEMKLTSVV 192
            :....:||.|:.:.|..:|:||||||||||::.:|.||:||||||       |||.:|      |
  Rat   220 KIFMFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE------V 278

  Fly   193 VTLWYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP 256
            ||||||.|:||| :..|::.:|:|...||::||...:.||||::.|.:|..||.|.|.|||:.||
  Rat   279 VTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPTEESWP 343

  Fly   257 QTISVA---LEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            ...|::   ..:||:..|:......|.|.....:||..:|.|:...|.||.|.|.|.|||
  Rat   344 GVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLTSLLLYESKSRMSAEAALSHPYFQ 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	119/296 (40%)
Cdk4	NP_001286493.1	S_TKc	26..312	CDD:214567	119/296 (40%)
Cdk18	NP_001093976.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..61
Cdk18	NP_001093976.1	PKc_like	115..402	CDD:419665	120/302 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910