Protein Alignment Cdk4 and csk1

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_593019.1
• Gene: csk1 / 2543327
• PomBaseID: SPAC1D4.06C
• Length: 306
• Species: Schizosaccharomyces pombe
• Alignment Length: 291
• Identity: 73/291 - (25%)
• Similarity: 134/291 - (46%)
• Gaps: 47/291 - (16%)

  Fly    38 GTVYRARDVITGNIVALKKVRISLNENGV-----PMSTLREISLLKQLNASNHANIVKLYEVCQF 97
            ||:   .:|..|.....||:.: :...|:     |...:|...:|:.:   .|.:|.::  |..|
pombe    20 GTI---SEVFVGERKNSKKLYV-IKVQGLVFKRPPHDAMRGKLILESI---GHPHIERI--VDSF 75

  Fly    98 LERD-GQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQ 161
            ::.: |.:.::..|:...  |||::|.:     |..|..::..::.:.:::|..|.|:|||:.|.
pombe    76 IDNEAGSVYLITSFKSFV--LSDVMDEI-----SIDTKCKIVLQISSALEYLEKHGILHRDIHPN 133

  Fly   162 NLLVSS-QGHLKIADFGLA--KTYGSE--MKLTSVVVTLWYRAPEVLL-AQPYNSTVDIWSAACI 220
            |:|:.| .|...::||.:|  |.:..|  .:|...:.|..|||.|.|. ...|...||.|:...:
pombe   134 NILLDSMNGPAYLSDFSIAWSKQHPGEEVQELIPQIGTGHYRAIETLFGCHSYGHEVDRWTFGIL 198

  Fly   221 IFEMFNRRALF-PGTSE--KNQL---DRIFELTGRPTEQQWPQTISVALEHFP-------QRHPK 272
            |.|:|:.:||| .|:||  .::|   ..|.:..|.|....||:     |..||       ..:|.
pombe   199 IAELFSNQALFDDGSSEGWPSELRLTSSIIQTLGTPNPSMWPE-----LSTFPDWNKFIFHEYPP 258

  Fly   273 RP-KDFCPHLCKYADDLLNKMLSYDLHLRPS 302
            :| .:..|.:......:::.:::|.....||
pombe   259 KPWSEILPSVDTSIQYIVSHLVTYSNRASPS 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	73/291 (25%)
csk1	NP_593019.1	Protein Kinases, catalytic domain	12..247	CDD:473864	66/247 (27%)