Protein Alignment Cdk4 and CDK20

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_047279074.1
• Gene: CDK20 / 23552
• HGNCID: 21420
• Length: 364
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 116/316 - (36%)
• Similarity: 170/316 - (53%)
• Gaps: 32/316 - (10%)

  Fly    26 YQELNIIGEGAYGTVYRARDV-------------ITGNIVALKKVRISLNENGVPMSTLREISLL 77
            |..|..|||||:|.|::|:.|             .||.|||||||.:...|:|.|...||||..|
Human     4 YCILGRIGEGAHGIVFKAKHVEPRVGWQCLPSILQTGEIVALKKVALRRLEDGFPNQALREIKAL 68

  Fly    78 KQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELL 142
            :::..:.:  :|:|..|  |....|   .:|.||.:..||:::: |..:..::...::...:.||
Human    69 QEMEDNQY--VVQLKAV--FPHGGG---FVLAFEFMLSDLAEVV-RHAQRPLAQAQVKSYLQMLL 125

  Fly   143 TGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTY---GSEM----KLTSVVVTLWYRAP 200
            .||.|.|::.|:||||||.|||:|:.|.|||||||||:.:   ||.:    ..||.:...|||||
Human   126 KGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATSPLPRRWYRAP 190

  Fly   201 EVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALE 264
            |:|. |:.|:..||:||..||:.|:.|...||||.::..||..:..:.|.|..|.||:...:...
Human   191 ELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDY 255

  Fly   265 H---FPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQEPL 317
            :   |.::.|...::..|.:...|.|||.:.|.|..|.|.:|...|.|.||...||
Human   256 NKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPL 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	112/309 (36%)
CDK20	XP_047279074.1	STKc_CCRK	3..307	CDD:270826	113/310 (36%)