Protein Alignment Cdk4 and CILK1

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001362326.1
• Gene: CILK1 / 22858
• HGNCID: 21219
• Length: 639
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 112/299 - (37%)
• Similarity: 167/299 - (55%)
• Gaps: 28/299 - (9%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVR---ISLNENGVPMSTLREISLLKQLNASNHAN 87
            |..:..:|:|.||:|...|.:.:|.::|:||::   .|..|    ...|||:..||:|   ||||
Human     4 YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE----CMNLREVKSLKKL---NHAN 61

  Fly    88 IVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDR----LPKSGMSPPTIQRLSRELLTGVDFL 148
            :|||.||.:  |.|.   :..:||:::::|..||..    .|:|     .|:.:..::|.|:.|:
Human    62 VVKLKEVIR--ENDH---LYFIFEYMKENLYQLIKERNKLFPES-----AIRNIMYQILQGLAFI 116

  Fly   149 HSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLL-AQPYNSTV 212
            |.|...||||||:|||......:||||||||:...|:...|..|.|.||||||||| :..|:|.:
Human   117 HKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPI 181

  Fly   213 DIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQ--TISVALE-HFPQRHPKRP 274
            |:|:..||:.|::..|.||||.||.:.:.:|.::.|.|.:..||:  .:|.|:. .:||..|...
Human   182 DVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNL 246

  Fly   275 KDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            |...|:....|..||..||.:|...||:|...|.:.|||
Human   247 KTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQ 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	109/296 (37%)
CILK1	NP_001362326.1	STKc_MAK_like	4..284	CDD:270824	109/296 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..344
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..488
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..639