DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk4 and Cdk16

DIOPT Version :9

Sequence 1:	NP_001286493.1	Gene:	Cdk4 / 36854	FlyBaseID:	FBgn0016131	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_035179.1	Gene:	Cdk16 / 18555	MGIID:	97516	Length:	496	Species:	Mus musculus

Alignment Length:	319	Identity:	119/319 - (37%)
Similarity:	186/319 - (58%)	Gaps:	30/319 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RQLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMS 69
            |:|:|..:|:   .|.|....|.:|:.:|||.|.|||:.:..:|.|:||||::|:. :|.|.|.:
Mouse   147 RRLRRVSLSE---IGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCT 207

  Fly    70 TLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTI 134
            .:||:||||.|   .|||||.|:::.. .|:.    :.||||::::||...:|.. .:.::...:
Mouse   208 AIREVSLLKDL---KHANIVTLHDIIH-TEKS----LTLVFEYLDKDLKQYLDDC-GNVINMHNV 263

  Fly   135 QRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLA-------KTYGSEMKLTSVV 192
            :....:||.|:.:.|..:::||||||||||::.:|.||:||||||       |||.:|      |
Mouse   264 KLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE------V 322

  Fly   193 VTLWYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP 256
            ||||||.|::|| :..|::.:|:|...||.:||...|.||||::.:.||..||.:.|.|||:.||
Mouse   323 VTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP 387

  Fly   257 QTIS---VALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF 312
            ..:|   ....::|:...:......|.|.....|||.|:|.::...|.||....:|.:|
Mouse   388 GILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARKHPFF 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	112/296 (38%)
Cdk4	NP_001286493.1	S_TKc	26..312	CDD:214567	112/296 (38%)
Cdk16	NP_035179.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95
Cdk16	NP_035179.1	STKc_PCTAIRE1	162..458	CDD:270854	113/301 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900