Protein Alignment Cdk4 and cdk-4

DIOPT Version :9

• Sequence 1: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_510256.1
• Gene: cdk-4 / 181472
• WormBaseID: WBGene00000406
• Length: 342
• Species: Caenorhabditis elegans
• Alignment Length: 312
• Identity: 122/312 - (39%)
• Similarity: 179/312 - (57%)
• Gaps: 6/312 - (1%)

  Fly     7 LKRQKMSQAKKFGD-GDPFNYQELNI---IGEGAYGTVYRARDVITGNIVALKKVRISLNENGVP 67
            |:.|||......|. ..|...::..|   :|:||||.|||.|.:..|...|||::.||....|:|
 Worm    15 LRLQKMMNNMTCGQMAKPLTMKDFQIHQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIP 79

  Fly    68 MSTLREISLLKQLNASNHANIVKLYEVCQFLERDGQLL-ILLVFEHVEQDLSDLIDRLPKSGMSP 131
            .|.||||:::|.|....|.||:.|..|...|:....:| |.::.|..:.||...:..:|: |:..
 Worm    80 QSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIPR-GVPE 143

  Fly   132 PTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLW 196
            ...:.::.:::..:||||:|.||||||||||:|::....:|:|||||:|.|.:....|::|||||
 Worm   144 QQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLW 208

  Fly   197 YRAPEVLLAQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISV 261
            ||:|||||...||||||:|:..||:.|::.|:.||.|.:|..||..||:..|.|..:.||....:
 Worm   209 YRSPEVLLQSYYNSTVDMWALGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVI 273

  Fly   262 ALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            |.:.|||..|...||..|.:.|.|.:.:.:.|.||...|.||...|.|.:.:
 Worm   274 ARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFLK 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	116/289 (40%)
		S_TKc	26..312	CDD:214567	116/289 (40%)
cdk-4	NP_510256.1	PKc_like	38..324	CDD:304357	116/286 (41%)
		S_TKc	38..324	CDD:214567	116/286 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156300
Domainoid	1	1.000	223	1.000	Domainoid score	I1463
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H963
Inparanoid	1	1.050	224	1.000	Inparanoid score	I2250
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D419040at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.810