Protein Alignment Cdk4 and cdk-11.2

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_509746.2
• Gene: cdk-11.2 / 181247
• WormBaseID: WBGene00013917
• Length: 668
• Species: Caenorhabditis elegans
• Alignment Length: 307
• Identity: 120/307 - (39%)
• Similarity: 176/307 - (57%)
• Gaps: 22/307 - (7%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVK 90
            |..||:|.||.||.|:|.::..|..:||||:.::...:.|.|::.||||::|  |.|..|.|||.
 Worm   304 YVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINML--LKAGAHENIVN 366

  Fly    91 LYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQR--LSRELLTGVDFLHSHRI 153
            :.|:   |....:..:.:..|:||.|:..|||::........|.|:  |..:||:|::.:|...|
 Worm   367 VKEI---LVGSTKTEVYMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLSGIEHMHKLWI 428

  Fly   154 IHRDLKPQNLLVSSQGHLKIADFGLAKTYG------SEMKLTSVVVTLWYRAPEVLL-AQPYNST 211
            :|||||..|||:|..|.|||||||||:.||      ..||||.:|||||||:||:|| .:.|::.
 Worm   429 LHRDLKTSNLLISHSGILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRSPELLLEPKTYSTP 493

  Fly   212 VDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKD 276
            ||:||..||:.|....:.:|.|.||.||:.:||::.|.||||.||....:.:.:..:..|.:|..
 Worm   494 VDMWSIGCIMAEFIMMKPMFQGDSEPNQVHQIFQMMGTPTEQIWPDIKELKVWNMVEFPPVKPGQ 558

  Fly   277 FCPHLCK-------YADDLLNKMLSYDLHLRPSALACLEHDYFQQEP 316
            . ..:.|       ...||||.||..:...|.:|...|:||:|.:.|
 Worm   559 L-RRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQHDWFSEHP 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	118/301 (39%)
cdk-11.2	NP_509746.2	Protein Kinases, catalytic domain	298..600	CDD:473864	118/301 (39%)