Protein Alignment Cdk4 and cdk-12

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001367220.1
• Gene: cdk-12 / 175559
• WormBaseID: WBGene00007135
• Length: 734
• Species: Caenorhabditis elegans
• Alignment Length: 311
• Identity: 115/311 - (36%)
• Similarity: 182/311 - (58%)
• Gaps: 22/311 - (7%)

  Fly    25 NYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIV 89
            :|..|:.||||.||.||:|.:.:||..||||:||:...:.|.|::.:|||.:|:||   :|.|||
 Worm   310 HYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQL---HHKNIV 371

  Fly    90 KLYEV------CQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFL 148
            :|.::      ...|:|. :....||||:|:.||..|::.......:...|..|.::||.|:.::
 Worm   372 RLMDIVIDDISMDELKRT-RANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYI 435

  Fly   149 HSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKL-TSVVVTLWYRAPEVLLA-QPYNST 211
            |:...:|||:|..|:||:::|.|||||.|||:.:..|.:| |:.|:|||||.||:||. :.|...
 Worm   436 HNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVITLWYRPPELLLGDERYGPA 500

  Fly   212 VDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQ-TISVALEHFPQR--HPKR 273
            :|:||..|::.|:|.|:.||.|.:|..||:.|.::.|.|....||: |..|....|..:  :.:|
 Worm   501 IDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFRMKRTYQRR 565

  Fly   274 PKDFCPHLC-KYADDLLNKMLSYDLHLRPSALACLEHDYFQQ------EPL 317
            .::...|:. :.|.|||:|||:.:...|.||...|.|.:.:.      :||
 Worm   566 IREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPL 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	113/297 (38%)
cdk-12	NP_001367220.1	STKc_CDK12	303..605	CDD:270847	113/298 (38%)