Protein Alignment Cdk4 and cdk-2

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001021537.2
• Gene: cdk-2 / 171911
• WormBaseID: WBGene00019362
• Length: 338
• Species: Caenorhabditis elegans
• Alignment Length: 297
• Identity: 115/297 - (38%)
• Similarity: 168/297 - (56%)
• Gaps: 23/297 - (7%)

  Fly    29 LNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVKLYE 93
            |..||||.||.|::|..|......|||.:|...:|.|:|.:.|||||.:|.|   .|.|||.|::
 Worm    18 LRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDL---QHDNIVTLFD 79

  Fly    94 VCQFLERDGQLLILLVFEHVEQDLSDLIDRL-PKSGMSPPT-IQRLSRELLTGVDFLHSHRIIHR 156
            :.....:     :.:|||.:::||.:|::.| |.:.:.||. ::....:||:.:.:.|..||:||
 Worm    80 IIYANSK-----LYMVFEFIDRDLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHR 139

  Fly   157 DLKPQNLLVSSQGHLKIADFGLAKTYG-SEMKLTSVVVTLWYRAPEVLL-AQPYNSTVDIWSAAC 219
            ||||||:|||..|.:||||||||:.:. .....|..|||||||.||:|| :|.|::::|:||..|
 Worm   140 DLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRYSTSLDMWSLGC 204

  Fly   220 IIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDF------- 277
            |..|:.:.:.||||..|.:||.:|||:.|.|..:.||...|  ..|:....|:.|.:.
 Worm   205 IFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDS--FPHYKAVFPQWPVNLKKLEETS 267

  Fly   278 CPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQ 314
            |  |.....|:|.::|.|....|.:|...|.|.||.|
 Worm   268 C--LTGNGLDVLREILRYPPERRLTAKGALSHRYFLQ 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	112/293 (38%)
cdk-2	NP_001021537.2	STKc_CDK_like	15..300	CDD:270823	112/293 (38%)