Protein Alignment Cdk4 and Cdk5

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_543161.1
• Gene: Cdk5 / 140908
• RGDID: 70514
• Length: 292
• Species: Rattus norvegicus
• Alignment Length: 297
• Identity: 132/297 - (44%)
• Similarity: 179/297 - (60%)
• Gaps: 24/297 - (8%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVK 90
            |::|..||||.||||::|::..|..|||||:||:..::.|||.|.||||.|||:|   .|.|||:
  Rat     4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL---KHKNIVR 65

  Fly    91 LYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIH 155
            |::|   |..|.:|  .||||..:|||....|.. ...:.|..::.|..:||.|:.|.||..::|
  Rat    66 LHDV---LHSDKKL--TLVFEFCDQDLKKYFDSC-NGDLDPEIVKSLLFQLLKGLGFCHSRNVLH 124

  Fly   156 RDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSV-VVTLWYRAPEVLL-AQPYNSTVDIWSAA 218
            |||||||||::..|.||:||||||:.:|..::..|. |||||||.|:||. |:.|::::|:|||.
  Rat   125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAG 189

  Fly   219 CIIFEMFNR-RALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFP--QRHPKRPK----- 275
            ||..|:.|. |.||||....:||.|||.|.|.|||:|||     |:...|  :.:|..|.
  Rat   190 CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP-----AMTKLPDYKPYPMYPATTSLV 249

  Fly   276 DFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF 312
            :..|.|.....|||..:|..:...|.||...|:|.||
  Rat   250 NVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	130/295 (44%)
Cdk5	NP_543161.1	STKc_CDK5	3..286	CDD:143344	130/295 (44%)