Protein Alignment Cdk4 and Cdk5

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_315787.4
• Gene: Cdk5 / 1276441
• VectorBaseID: AGAMI1_003707
• Length: 289
• Species: Anopheles gambiae
• Alignment Length: 294
• Identity: 133/294 - (45%)
• Similarity: 178/294 - (60%)
• Gaps: 14/294 - (4%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVK 90
            |::|..||||.||||::.::..|..|||||:||:..::.|||.|.||||.|||:|   .|.|||:
Mosquito     4 YEKLEKIGEGTYGTVFKGKNRDTLEIVALKRVRLDEDDEGVPSSALREICLLKEL---KHKNIVR 65

  Fly    91 LYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIH 155
            ||:|   |..|.:|  .|||||.:|||....|.| ...:.|..::....:||.|:.|.|||.::|
Mosquito    66 LYDV---LHSDKKL--TLVFEHCDQDLKKYFDSL-NGEIDPDVVKSFMYQLLRGLAFCHSHNVLH 124

  Fly   156 RDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSV-VVTLWYRAPEVLL-AQPYNSTVDIWSAA 218
            |||||||||::..|.||:||||||:.:|..:|..|. |||||||.|:||. |:.|.:::|:|||.
Mosquito   125 RDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAG 189

  Fly   219 CIIFEMFNR-RALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVA-LEHFPQRHPKRP-KDFCPH 280
            ||..|:.|. |.||||:...:||.|||:|.|.|.|:.||....:: .:.||...|... ....|.
Mosquito   190 CIFAELANAGRPLFPGSDVDDQLKRIFKLLGTPEEENWPGITQLSDYKPFPLYPPTTSWSQVVPR 254

  Fly   281 LCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQ 314
            |.....|||.|:|.....||.||...:.|.||.:
Mosquito   255 LNSKGRDLLQKLLVCRPLLRLSAEQAMSHPYFTE 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	131/290 (45%)
Cdk5	XP_315787.4	STKc_CDK5	3..286	CDD:143344	131/290 (45%)