Protein Alignment Cdk4 and Cdk7

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_312281.3
• Gene: Cdk7 / 1273315
• VectorBaseID: AGAMI1_011913
• Length: 343
• Species: Anopheles gambiae
• Alignment Length: 304
• Identity: 124/304 - (40%)
• Similarity: 178/304 - (58%)
• Gaps: 29/304 - (9%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNE---NGVPMSTLREISLLKQLNASNHAN 87
            |::::.:|||.:.|||:|||..|..|||:||::|...|   :|:..:.||||.||.:|   .|.|
Mosquito    10 YEKIDFLGEGQFATVYKARDAETNEIVAVKKIKIGNREEAADGINRTALREIKLLHEL---QHEN 71

  Fly    88 IVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHR 152
            |:.|.:|  |..:..   :.|||:.::.|| ::|.:.||..::|..|:....:.|.|:::||.|.
Mosquito    72 IIGLLDV--FGHKSN---VSLVFDFMDTDL-EIIIKDPKIILTPANIKSYMIQTLRGLEYLHQHW 130

  Fly   153 IIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKL-TSVVVTLWYRAPEVLL-AQPYNSTVDIW 215
            |:||||||.|||:|..|.|||.||||||.:||..:: |:.|||.|||.||:|. |:.|...||||
Mosquito   131 ILHRDLKPNNLLISGTGVLKIGDFGLAKFFGSPNRINTNQVVTRWYRCPELLFGARQYGIGVDIW 195

  Fly   216 SAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTIS----VALEHFPQRHPKRPKD 276
            :..||:.|:..|....||.|:.:||.|||::.|.|.|..||...|    |..:.:|   |...:|
Mosquito   196 AVGCILAELLLRVPFLPGESDLDQLTRIFQVLGTPNETNWPDVKSLPDYVQYKFYP---PIPLRD 257

  Fly   277 FCPHLCKYADDLL---NKMLS-YDLHLRPSALACLEHDYFQQEP 316
            .   ....:|||:   ||||: |.|| |.|....|:..||..:|
Mosquito   258 I---FTAASDDLIELANKMLALYPLH-RCSCTEALKMAYFSNKP 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	121/298 (41%)
Cdk7	XP_312281.3	STKc_CDK7	9..306	CDD:270833	124/304 (41%)