Protein Alignment Cdk4 and Cdk4

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_034000.1
• Gene: Cdk4 / 12567
• MGIID: 88357
• Length: 303
• Species: Mus musculus
• Alignment Length: 293
• Identity: 138/293 - (47%)
• Similarity: 194/293 - (66%)
• Gaps: 3/293 - (1%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRI---SLNENGVPMSTLREISLLKQLNASNHAN 87
            |:.:..||.|||||||:|||..:|:.||||.||:   .....|:|:||:||::||::|.|..|.|
Mouse     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPN 70

  Fly    88 IVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHR 152
            :|:|.:||.....|..:.:.|||||::|||...:|:.|..|:...||:.|.|:.|:|:||||::.
Mouse    71 VVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANC 135

  Fly   153 IIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSA 217
            |:||||||:|:||:|.|.:|:||||||:.|..:|.||.||||||||||||||...|.:.||:||.
Mouse   136 IVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSV 200

  Fly   218 ACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLC 282
            .||..|||.|:.||.|.||.:||.:||:|.|.|.|..||:.:|:....|..|.|:..:...|.:.
Mouse   201 GCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVPEME 265

  Fly   283 KYADDLLNKMLSYDLHLRPSALACLEHDYFQQE 315
            :....||.:||:::.|.|.||...|:|.|..:|
Mouse   266 ESGAQLLLEMLTFNPHKRISAFRALQHSYLHKE 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	136/288 (47%)
Cdk4	NP_034000.1	STKc_CDK4	5..295	CDD:143368	137/291 (47%)
		Required for binding D-type cyclins. /evidence=ECO:0000250	50..56		3/5 (60%)