Protein Alignment Cdk4 and Cdk2

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_904326.1
• Gene: Cdk2 / 12566
• MGIID: 104772
• Length: 346
• Species: Mus musculus
• Alignment Length: 346
• Identity: 144/346 - (41%)
• Similarity: 188/346 - (54%)
• Gaps: 70/346 - (20%)

  Fly    25 NYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIV 89
            |:|::..||||.||.||:|::.:||.:|||||:|:.....|||.:.:|||||||:|   ||.|||
Mouse     3 NFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL---NHPNIV 64

  Fly    90 KLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRII 154
            ||.:|   :..:.:|  .||||.:.|||...:|....:|:..|.|:....:||.|:.|.||||::
Mouse    65 KLLDV---IHTENKL--YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124

  Fly   155 HRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLLAQPYNST-VDIWSA 217
            ||||||||||::::|.:|:||||||:.:|..:: .|..||||||||||:||...|.|| |||||.
Mouse   125 HRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189

  Fly   218 ACIIFEM------------------------------------------------FNRRALFPGT 234
            .||..||                                                ..|||||||.
Mouse   190 GCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVAASQGGGMTAVSAPHPVTRRALFPGD 254

  Fly   235 SEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPK----DF---CPHLCKYADDLLNKM 292
            ||.:||.|||...|.|.|..||...|:     |...|..||    ||   .|.|.:....||::|
Mouse   255 SEIDQLFRIFRTLGTPDEVVWPGVTSM-----PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQM 314

  Fly   293 LSYDLHLRPSALACLEHDYFQ 313
            |.||.:.|.||.|.|.|.:||
Mouse   315 LHYDPNKRISAKAALAHPFFQ 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	141/342 (41%)
Cdk2	NP_904326.1	STKc_CDK2_3	3..334	CDD:270844	142/343 (41%)