Protein Alignment Cdk4 and CDK9

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001252.1
• Gene: CDK9 / 1025
• HGNCID: 1780
• Length: 372
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 116/326 - (35%)
• Similarity: 181/326 - (55%)
• Gaps: 30/326 - (9%)

  Fly    15 AKKFGDGD-PF-----NYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLRE 73
            ||::...: ||     .|::|..||:|.:|.|::||...||..||||||.:...:.|.|::.|||
Human     2 AKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66

  Fly    74 ISLLKQLNASNHANIVKLYEVCQ-----FLERDGQLLILLVFEHVEQDLSDLIDR-LPKSGMSPP 132
            |.:|:.|   .|.|:|.|.|:|:     :....|.  |.|||:..|.||:.|:.. |.|..:|
Human    67 IKILQLL---KHENVVNLIEICRTKASPYNRCKGS--IYLVFDFCEHDLAGLLSNVLVKFTLS-- 124

  Fly   133 TIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTY-----GSEMKLTSVV 192
            .|:|:.:.||.|:.::|.::|:|||:|..|:|::..|.||:||||||:.:     ....:.|:.|
Human   125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189

  Fly   193 VTLWYRAPEVLLAQ-PYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP 256
            ||||||.||:||.: .|...:|:|.|.||:.||:.|..:..|.:|::||..|.:|.|..|.:.||
Human   190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254

  Fly   257 QTISVALE---HFPQRHPKRPKDFCPHLCK--YADDLLNKMLSYDLHLRPSALACLEHDYFQQEP 316
            ...:..|.   ...:...::.||......:  ||.||::|:|..|...|..:...|.||:|..:|
Human   255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDP 319

  Fly   317 L 317
            :
Human   320 M 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	110/302 (36%)
CDK9	NP_001252.1	STKc_CDK9	6..315	CDD:270848	112/315 (36%)
		T-loop	166..191		8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372