Protein Alignment Cdk4 and CDK7

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001790.1
• Gene: CDK7 / 1022
• HGNCID: 1778
• Length: 346
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 128/324 - (39%)
• Similarity: 179/324 - (55%)
• Gaps: 51/324 - (15%)

  Fly    13 SQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRI---SLNENGVPMSTLREI 74
            |:||:        |::|:.:|||.:.|||:|||..|..|||:||:::   |..::|:..:.||||
Human     7 SRAKR--------YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63

  Fly    75 SLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSG---MSPPTIQR 136
            .||::|   :|.||:.|.:.  |..:..   |.|||:.:|.||..:|    |..   ::|..|:.
Human    64 KLLQEL---SHPNIIGLLDA--FGHKSN---ISLVFDFMETDLEVII----KDNSLVLTPSHIKA 116

  Fly   137 LSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAP 200
            .....|.|:::||.|.|:||||||.|||:...|.||:|||||||::||..: .|..|||.|||||
Human   117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181

  Fly   201 EVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTIS---- 260
            |:|. |:.|...||:|:..||:.|:..|....||.|:.:||.||||..|.|||:|||...|
Human   182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246

  Fly   261 VALEHFP--QRHPKRPKDFCPHLCKYA-DDLLNKMLSYDLHL-----RPSALACLEHDYFQQEP 316
            |..:.||  ..|         |:...| ||||:  |...|.|     |.:|...|:..||...|
Human   247 VTFKSFPGIPLH---------HIFSAAGDDLLD--LIQGLFLFNPCARITATQALKMKYFSNRP 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	122/305 (40%)
CDK7	NP_001790.1	STKc_CDK7	11..308	CDD:270833	125/320 (39%)