Protein Alignment Cdk4 and CDK6

DIOPT Version :9

• Sequence 1: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001138778.1
• Gene: CDK6 / 1021
• HGNCID: 1777
• Length: 326
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 135/289 - (46%)
• Similarity: 198/289 - (68%)
• Gaps: 1/289 - (0%)

  Fly    26 YQELNIIGEGAYGTVYRARDVIT-GNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIV 89
            |:.:..|||||||.|::|||:.. |..||||:||:...|.|:|:||:||:::|:.|....|.|:|
Human    13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77

  Fly    90 KLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRII 154
            :|::||.....|.:..:.||||||:|||:..:|::|:.|:...||:.:..:||.|:|||||||::
Human    78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVV 142

  Fly   155 HRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSAAC 219
            ||||||||:||:|.|.:|:||||||:.|..:|.|||||||||||||||||...|.:.||:||..|
Human   143 HRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGC 207

  Fly   220 IIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLCKY 284
            |..|||.|:.||.|:|:.:||.:|.::.|.|.|:.||:.:::..:.|..:..:..:.|...:.:.
Human   208 IFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDEL 272

  Fly   285 ADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            ..|||.|.|:::...|.||.:.|.|.|||
Human   273 GKDLLLKCLTFNPAKRISAYSALSHPYFQ 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	132/286 (46%)
		S_TKc	26..312	CDD:214567	132/286 (46%)
CDK6	NP_001138778.1	STKc_CDK6	11..300	CDD:270846	132/286 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1720
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H963
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2907
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D419040at33208
OrthoFinder	1	1.000	-	-		FOG0004605
OrthoInspector	1	1.000	-	-		otm41504
orthoMCL	1	0.900	-	-		OOG6_108285
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.830