Protein Alignment Cdk4 and CDK4

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_000066.1
• Gene: CDK4 / 1019
• HGNCID: 1773
• Length: 303
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 139/293 - (47%)
• Similarity: 195/293 - (66%)
• Gaps: 3/293 - (1%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRI---SLNENGVPMSTLREISLLKQLNASNHAN 87
            |:.:..||.|||||||:|||..:|:.||||.||:   .....|:|:||:||::||::|.|..|.|
Human     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70

  Fly    88 IVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHR 152
            :|:|.:||.....|.::.:.||||||:|||...:|:.|..|:...||:.|.|:.|.|:||||::.
Human    71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC 135

  Fly   153 IIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSA 217
            |:||||||:|:||:|.|.:|:||||||:.|..:|.||.||||||||||||||...|.:.||:||.
Human   136 IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSV 200

  Fly   218 ACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLC 282
            .||..|||.|:.||.|.||.:||.:||:|.|.|.|..||:.:|:....||.|.|:..:...|.:.
Human   201 GCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEME 265

  Fly   283 KYADDLLNKMLSYDLHLRPSALACLEHDYFQQE 315
            :....||.:||:::.|.|.||...|:|.|..::
Human   266 ESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	138/288 (48%)
CDK4	NP_000066.1	Protein Kinases, catalytic domain	5..295	CDD:473864	138/288 (48%)
		Required for binding D-type cyclins	50..56		3/5 (60%)