Protein Alignment Cdk4 and CDK3

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001249.1
• Gene: CDK3 / 1018
• HGNCID: 1772
• Length: 305
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 136/296 - (45%)
• Similarity: 180/296 - (60%)
• Gaps: 13/296 - (4%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVK 90
            :|::..||||.||.||:|::..||.:|||||:|:.|...|||.:.:|||||||:|   .|.|||:
Human     4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKEL---KHPNIVR 65

  Fly    91 LYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIH 155
            |.:|..     .:..:.||||.:.|||...:|..|.|.:....|:....:||.||.|.||||:||
Human    66 LLDVVH-----NERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIH 125

  Fly   156 RDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLLAQP-YNSTVDIWSAA 218
            |||||||||::..|.:|:||||||:.:|..:: .|..||||||||||:||... |.:.|||||..
Human   126 RDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIG 190

  Fly   219 CIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVA--LEHFPQRHPKRPKDFCPHL 281
            ||..||..|:|||||.||.:||.|||.:.|.|:|..||....:.  ...||:...|..::..|:|
Human   191 CIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNL 255

  Fly   282 CKYADDLLNKMLSYDLHLRPSALACLEHDYFQQ-EP 316
            .....|||.::|.||...|.:|...|.|.||.. ||
Human   256 EPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEP 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	132/289 (46%)
CDK3	NP_001249.1	STKc_CDK2_3	3..286	CDD:270844	132/289 (46%)