Protein Alignment Cdk4 and cilk1

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_002934912.3
• Gene: cilk1 / 100498050
• XenbaseID: XB-GENE-985841
• Length: 623
• Species: Xenopus tropicalis
• Alignment Length: 299
• Identity: 112/299 - (37%)
• Similarity: 167/299 - (55%)
• Gaps: 28/299 - (9%)

  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVR---ISLNENGVPMSTLREISLLKQLNASNHAN 87
            |..:..:|:|.||:|...|.|.:|.:||:||::   .|.:|    ...|||:..||:|   ||||
 Frog     4 YTTVKQLGDGTYGSVILGRSVESGELVAIKKMKRKFYSWDE----CMNLREVKSLKKL---NHAN 61

  Fly    88 IVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLI-DR---LPKSGMSPPTIQRLSRELLTGVDFL 148
            ::||.||   :..:.||  ..|||:::::|..|: ||   .|:|     .|:.:..::|.|:.::
 Frog    62 VIKLKEV---IRENNQL--YFVFEYMKENLYQLMKDRNKLFPES-----IIRNIMYQILQGLAYI 116

  Fly   149 HSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLL-AQPYNSTV 212
            |.:...||||||:|||......:||||||||:...|....|..|.|.||||||||| |..|||.:
 Frog   117 HKYGFFHRDLKPENLLCMGPELVKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRATNYNSPI 181

  Fly   213 DIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVA-LEHFPQRH--PKRP 274
            |||:..||:.|::..|.||||:||.:.:.:|.::.|.|.:..|.:...:| ..:|...|  |...
 Frog   182 DIWAVGCIMAEIYTLRPLFPGSSEVDTIFKICQVLGTPKKNDWFEGFQLASAMNFRWAHCVPSNL 246

  Fly   275 KDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            |...|:.|.....::..||.:|...||:|...|.:.|||
 Frog   247 KTLIPNACADGIQVMRDMLQWDPKKRPTASQALRYSYFQ 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	109/296 (37%)
cilk1	XP_002934912.3	STKc_MAK_like	4..284	CDD:270824	109/296 (37%)