Protein Alignment Cdk4 and cdk12

DIOPT Version :10

• Sequence 1: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_012826946.1
• Gene: cdk12 / 100038049
• XenbaseID: XB-GENE-493308
• Length: 1466
• Species: Xenopus tropicalis
• Alignment Length: 313
• Identity: 113/313 - (36%)
• Similarity: 172/313 - (54%)
• Gaps: 37/313 - (11%)

  Fly    22 DPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHA 86
            |.|:.  :.|||||.||.||:|:|..||.:|||||||:...:.|.|::.:|||.:|:||   .|.
 Frog   708 DKFDI--IGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQL---IHK 767

  Fly    87 NIVKLYEV-------CQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGM---SPPTIQRLSREL 141
            ::|.:.|:       ..|.:..|  ...||||:::.||..|::    ||:   |...|:...::|
 Frog   768 SVVNMKEIVTDKQDALDFKKDKG--AFYLVFEYMDHDLMGLLE----SGLVQFSEDHIKSFMKQL 826

  Fly   142 LTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSE--MKLTSVVVTLWYRAPEVLL 204
            :.|:::.|....:|||:|..|:|:::.|.:|:||||||:.|.||  ...|:.|:|||||.||:||
 Frog   827 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLL 891

  Fly   205 AQP-YNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQ 268
            .:. |...:|:||..||:.|:|.::.:|....|..||:.|..|.|.|....||..|.  |.:|..
 Frog   892 GEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIK--LPYFNT 954

  Fly   269 RHPKRPK--------DFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313
            ..||:..        .|.|   ..|.|||:.||:.|...|.:|...|:.|:.:
 Frog   955 MKPKKQYRRRLREEFSFVP---TPALDLLDHMLTLDPSKRCTAEQTLQSDFLK 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	111/306 (36%)
cdk12	XP_012826946.1	STKc_CDK12	702..1003	CDD:270847	113/310 (36%)