DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4927 and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_001033953.1	Gene:	CG4927 / 36852	FlyBaseID:	FBgn0034139	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	257	Identity:	78/257 - (30%)
Similarity:	123/257 - (47%)	Gaps:	34/257 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 IVGGAKAAGREFPFMALLGQRGKNSSQIDWDCGAIIIHPKFVLTAAHCLETSETKEQRLDPNYDG 169
            ||||..|....:|:...|..:..:.      ||..||.|::::|||||:      |:.|:..:..
Human   293 IVGGESALPGAWPWQVSLHVQNVHV------CGGSIITPEWIVTAAHCV------EKPLNNPWHW 345

  Fly   170 PKY--VVRLGELDYNSTTDDAQPQDFRVLNYVVHPAYGEDDDTGSRKNDIAVVELEMEATFSEYV 232
            ..:  ::|...:.|.:        .::|...:.||.|    |:.::.||||:::|:...||::.|
Human   346 TAFAGILRQSFMFYGA--------GYQVEKVISHPNY----DSKTKNNDIALMKLQKPLTFNDLV 398

  Fly   233 APACLPLDG---GNEQLQVAAAGWGATSESGHASSHLLKVSLDRYDVAECSQRLEH-KIDVRTQL 293
            .|.|||..|   ..||| ...:|||||.|.|..|..|....:...:...|:.|..: .:.....:
Human   399 KPVCLPNPGMMLQPEQL-CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMI 462

  Fly   294 CAGSRSTSADTCYGDSGGPVFVQHPIYSCLKQVIGITSYGLVCGVQGLPSVYTKVHLYTDWI 355
            |||....:.|:|.||||||:....   :.:..:||.||:|..|.....|.||..|.::||||
Human   463 CAGFLQGNVDSCQGDSGGPLVTSK---NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	78/257 (30%)
CG4927	NP_001033953.1	Tryp_SPc	105..355	CDD:214473	76/255 (30%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133
		Tryp_SPc	292..521	CDD:214473	76/255 (30%)
		Tryp_SPc	293..524	CDD:238113	78/257 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910