DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4927 and F12

DIOPT Version :9

Sequence 1:	NP_001033953.1	Gene:	CG4927 / 36852	FlyBaseID:	FBgn0034139	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_067464.2	Gene:	F12 / 58992	MGIID:	1891012	Length:	597	Species:	Mus musculus

Alignment Length:	343	Identity:	92/343 - (26%)
Similarity:	135/343 - (39%)	Gaps:	71/343 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ECKELSATDCPSIFFNLHLIRNFVKYCDKSNHIVCCLLPNNMQPQSQQFSANIGLRRFEKECRRF 92
            |.:|.|.:..||:....:         |.::|.......|.|         ..| :||.|....|
Mouse   307 ESQEESPSQAPSLSHAPN---------DSTDHQTSLSKTNTM---------GCG-QRFRKGLSSF 352

  Fly    93 NEIRTSCRTTPFIVGGAKAAGREFPFMALLGQRGKNSSQIDWDCGAIIIHPKFVLTAAHCLETSE 157
            ..          :|||..|.....|::|.| ..|.|.      |...:|.|.:||||||||:...
Mouse   353 MR----------VVGGLVALPGSHPYIAAL-YWGNNF------CAGSLIAPCWVLTAAHCLQNRP 400

  Fly   158 TKEQRLDPNYDGPKYVVRLGELDYNSTTDDAQPQDFRVLNYVVHPAYGEDDDTGSRKNDIAVVEL 222
            ..|:          ..|.||:..:|.:.:..  |...|.:|.:|..:    .:.:.::|:|::.|
Mouse   401 APEE----------LTVVLGQDRHNQSCEWC--QTLAVRSYRLHEGF----SSITYQHDLALLRL 449

  Fly   223 EMEAT-----FSEYVAPACLPLDGG--NEQLQVAAAGWGATSESGHASSHLLK------VSLDRY 274
            :...|     .|.:|.|.|||....  :|.:....||||...|.....|..|:      ::|||
Mouse   450 QESKTNSCAILSPHVQPVCLPSGAAPPSETVLCEVAGWGHQFEGAEEYSTFLQEAQVPFIALDR- 513

  Fly   275 DVAECSQRLEHKIDVRT-QLCAGSRSTSADTCYGDSGGPVFVQHPIYSCLKQVIGITSYGLVCGV 338
                ||....|...:.. .||||......|.|.||||||:..:.........:.|:.|:|..||.
Mouse   514 ----CSNSNVHGDAILPGMLCAGFLEGGTDACQGDSGGPLVCEEGTAEHQLTLRGVISWGSGCGD 574

  Fly   339 QGLPSVYTKVHLYTDWIE 356
            :..|.|||.|..|..||:
Mouse   575 RNKPGVYTDVANYLAWIQ 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	78/266 (29%)
CG4927	NP_001033953.1	Tryp_SPc	105..355	CDD:214473	76/263 (29%)
F12	NP_067464.2	FN2	41..88	CDD:238019
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		KR	217..295	CDD:294073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..338		7/39 (18%)
		Tryp_SPc	354..591	CDD:214473	76/274 (28%)
		Tryp_SPc	355..594	CDD:238113	78/266 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960