DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4927 and MASP1

DIOPT Version :9

Sequence 1:	NP_001033953.1	Gene:	CG4927 / 36852	FlyBaseID:	FBgn0034139	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	420	Identity:	107/420 - (25%)
Similarity:	151/420 - (35%)	Gaps:	117/420 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CDNGTGECKELSATDCPSIFFNLHLIR-----NFVKYCDKSNHIVCCLLPNNMQPQSQQFSANIG 81
            ||.|....|:....|.    |.:..::     |.:..|    .||.|..|..::.....||....
Human   336 CDTGYKVLKDNVEMDT----FQIECLKDGTWSNKIPTC----KIVDCRAPGELEHGLITFSTRNN 392

  Fly    82 LRRFEKECRRFNEIRTSC-------------------------------------------RTTP 103
            |..::      :||:.||                                           |:.|
Human   393 LTTYK------SEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSLPTCLPECGQPSRSLP 451

  Fly   104 F----IVGGAKAAGREFPFMALLGQRGKNSSQI---DWDCGAIIIHPKFVLTAAHCLETSETKEQ 161
            .    |:||..|....||:.||:..  :::|::   .|.....::...::|||||.|     :.|
Human   452 SLVKRIIGGRNAEPGLFPWQALIVV--EDTSRVPNDKWFGSGALLSASWILTAAHVL-----RSQ 509

  Fly   162 RLDPN---YDGPKYVVRLGELDYNSTTDDAQPQDFRVLNYVVHPAYGEDDDTGSRKNDIAVVELE 223
            |.|..   .......|.||..|....:........||   |:||    |.:..:..:|||:|:|:
Human   510 RRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARV---VLHP----DFNIQNYNHDIALVQLQ 567

  Fly   224 MEATFSEYVAPACLPL---DGGNEQLQVAAAGWGATS---------ESG--HASSHLLKVSLDRY 274
            .......:|.|.|||.   :|....:....||||.::         .||  ..|..|..|.|...
Human   568 EPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVV 632

  Fly   275 DVAECSQRLEHKID----VRTQLCAGSRSTSADTCYGDSGGPVFVQHPIYSCLKQ---VIGITSY 332
            ..|||....|.:..    .....|||......|||.||||| .||   |:..|.|   |.|:.|:
Human   633 PHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGG-AFV---IFDDLSQRWVVQGLVSW 693

  Fly   333 G--LVCGVQGLPSVYTKVHLYTDWIENIVW 360
            |  ..||.:.:..|||||..|.||    ||
Human   694 GGPEECGSKQVYGVYTKVSNYVDW----VW 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	84/281 (30%)
CG4927	NP_001033953.1	Tryp_SPc	105..355	CDD:214473	83/278 (30%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512	7/36 (19%)
		CCP	374..439	CDD:153056	9/70 (13%)
		Tryp_SPc	456..718	CDD:214473	84/283 (30%)
		Tryp_SPc	457..718	CDD:238113	84/282 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910